| Autor: |
Gruzdeva OV; Federal State Budgetary Scientific Institution 'Research Institute for Complex Issues of Cardiovascular Diseases', 650002 Kemerovo, Russia., Dyleva YA; Federal State Budgetary Scientific Institution 'Research Institute for Complex Issues of Cardiovascular Diseases', 650002 Kemerovo, Russia., Belik EV; Federal State Budgetary Scientific Institution 'Research Institute for Complex Issues of Cardiovascular Diseases', 650002 Kemerovo, Russia., Sinitsky MY; Federal State Budgetary Scientific Institution 'Research Institute for Complex Issues of Cardiovascular Diseases', 650002 Kemerovo, Russia., Stasev AN; Federal State Budgetary Scientific Institution 'Research Institute for Complex Issues of Cardiovascular Diseases', 650002 Kemerovo, Russia., Kokov AN; Federal State Budgetary Scientific Institution 'Research Institute for Complex Issues of Cardiovascular Diseases', 650002 Kemerovo, Russia., Brel NK; Federal State Budgetary Scientific Institution 'Research Institute for Complex Issues of Cardiovascular Diseases', 650002 Kemerovo, Russia., Krivkina EO; Federal State Budgetary Scientific Institution 'Research Institute for Complex Issues of Cardiovascular Diseases', 650002 Kemerovo, Russia., Bychkova EE; Federal State Budgetary Scientific Institution 'Research Institute for Complex Issues of Cardiovascular Diseases', 650002 Kemerovo, Russia., Tarasov RS; Federal State Budgetary Scientific Institution 'Research Institute for Complex Issues of Cardiovascular Diseases', 650002 Kemerovo, Russia., Barbarash OL; Federal State Budgetary Scientific Institution 'Research Institute for Complex Issues of Cardiovascular Diseases', 650002 Kemerovo, Russia. |
| Abstrakt: |
Adipose tissue (AT) is an endocrine and paracrine organ that synthesizes biologically active adipocytokines, which affect inflammation, fibrosis, and atherogenesis. Epicardial and perivascular fat depots are of great interest to researchers, owing to their potential effects on the myocardium and blood vessels. The aim of the study was to assess the expression and secretion of adipocytokine genes in the AT of patients with coronary artery disease (CAD) and patients with aortic or mitral valve replacement. This study included 84 patients with CAD and 50 patients with aortic or mitral valve replacement. Adipocytes were isolated from subcutaneous, epicardial (EAT), and perivascular AT (PVAT), and were cultured for 24 h. EAT exhibited the lowest level of adiponectin gene expression and secretion, regardless of nosology, and high expression levels of the leptin gene and interleukin-6 (IL-6). However, EAT adipocytes in patients with CAD were characterized by more pronounced changes in comparison with the group with heart defects. High leptin and IL-6 levels resulted in increased pro-inflammatory activity, as observed in both EAT and PVAT adipocytes, especially in individuals with CAD. Therefore, our results revealed the pathogenetic significance of alterations in the adipokine and cytokine status of adipocytes of EAT and PVAT in patients with CAD. |
