| Autor: |
Durán-Saenz NZ; Biomedical Sciences, Autonomous University of Zacatecas, Zacatecas 98160, Mexico.; Academic Unit of Biological Sciences, Autonomous University of Zacatecas, Zacatecas 98068, Mexico., Serrano-Puente A; Biomedical Sciences, Autonomous University of Zacatecas, Zacatecas 98160, Mexico.; Academic Unit of Biological Sciences, Autonomous University of Zacatecas, Zacatecas 98068, Mexico., Gallegos-Flores PI; Academic Unit of Biological Sciences, Autonomous University of Zacatecas, Zacatecas 98068, Mexico., Mendoza-Almanza BD; Academic Unit of Biological Sciences, Autonomous University of Zacatecas, Zacatecas 98068, Mexico., Esparza-Ibarra EL; Academic Unit of Biological Sciences, Autonomous University of Zacatecas, Zacatecas 98068, Mexico., Godina-González S; Academic Unit of Chemical Sciences, Autonomous University of Zacatecas, Zacatecas 98160, Mexico., González-Curiel IE; Biomedical Sciences, Autonomous University of Zacatecas, Zacatecas 98160, Mexico.; Academic Unit of Chemical Sciences, Autonomous University of Zacatecas, Zacatecas 98160, Mexico., Ayala-Luján JL; Biomedical Sciences, Autonomous University of Zacatecas, Zacatecas 98160, Mexico.; Academic Unit of Chemical Sciences, Autonomous University of Zacatecas, Zacatecas 98160, Mexico., Hernández-Barrales M; Academic Unit of Chemical Sciences, Autonomous University of Zacatecas, Zacatecas 98160, Mexico., Cueto-Villalobos CF; Academic Unit of Chemical Sciences, Autonomous University of Zacatecas, Zacatecas 98160, Mexico., Frausto-Fierros SY; Academic Unit of Chemical Sciences, Autonomous University of Zacatecas, Zacatecas 98160, Mexico., Burciaga-Hernandez LA; Biomedical Sciences, Autonomous University of Zacatecas, Zacatecas 98160, Mexico.; Academic Unit of Biological Sciences, Autonomous University of Zacatecas, Zacatecas 98068, Mexico., Mendoza-Almanza G; Biomedical Sciences, Autonomous University of Zacatecas, Zacatecas 98160, Mexico.; Academic Unit of Biological Sciences, Autonomous University of Zacatecas, Zacatecas 98068, Mexico.; Academic Unit of Chemical Sciences, Autonomous University of Zacatecas, Zacatecas 98160, Mexico.; National Council of Science and Technology, Autonomous University of Zacatecas, Zacatecas 98000, Mexico. |
| Abstrakt: |
In addition to being biological barriers where the internalization or release of biomolecules is decided, cell membranes are contact structures between the interior and exterior of the cell. Here, the processes of cell signaling mediated by receptors, ions, hormones, cytokines, enzymes, growth factors, extracellular matrix (ECM), and vesicles begin. They triggering several responses from the cell membrane that include rearranging its components according to the immediate needs of the cell, for example, in the membrane of platelets, the formation of filopodia and lamellipodia as a tissue repair response. In cancer, the cancer cells must adapt to the new tumor microenvironment (TME) and acquire capacities in the cell membrane to transform their shape, such as in the case of epithelial-mesenchymal transition (EMT) in the metastatic process. The cancer cells must also attract allies in this challenging process, such as platelets, fibroblasts associated with cancer (CAF), stromal cells, adipocytes, and the extracellular matrix itself, which limits tumor growth. The platelets are enucleated cells with fairly interesting growth factors, proangiogenic factors, cytokines, mRNA, and proteins, which support the development of a tumor microenvironment and support the metastatic process. This review will discuss the different actions that platelet membranes and cancer cell membranes carry out during their relationship in the tumor microenvironment and metastasis. |
