A SARS-CoV-2 Infection High-Uptake Program on Healthcare Workers and Cancer Patients of the National Cancer Institute of Naples, Italy.

Autor:	Crispo A; Epidemiology and Biostatistics Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Pascale'-IRCCS, 80131 Naples, Italy., Di Gennaro P; Epidemiology and Biostatistics Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Pascale'-IRCCS, 80131 Naples, Italy., Coluccia S; Epidemiology and Biostatistics Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Pascale'-IRCCS, 80131 Naples, Italy., Gandini S; Department of Experimental Oncology, European Institute of Oncology (IEO)-IRCCS, 20141 Milan, Italy., Montagnese C; Epidemiology and Biostatistics Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Pascale'-IRCCS, 80131 Naples, Italy., Porciello G; Epidemiology and Biostatistics Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Pascale'-IRCCS, 80131 Naples, Italy., Nocerino F; Epidemiology and Biostatistics Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Pascale'-IRCCS, 80131 Naples, Italy., Grimaldi M; Epidemiology and Biostatistics Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Pascale'-IRCCS, 80131 Naples, Italy., Tafuri M; Epidemiology and Biostatistics Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Pascale'-IRCCS, 80131 Naples, Italy., Luongo A; Epidemiology and Biostatistics Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Pascale'-IRCCS, 80131 Naples, Italy., Rotondo E; Epidemiology and Biostatistics Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Pascale'-IRCCS, 80131 Naples, Italy., Amore A; Division of Surgery of Melanoma and Skin Cancer, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Pascale'-IRCCS, 80131 Naples, Italy., Labonia F; Laboratory Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Pascale'-IRCCS, 80131 Naples, Italy., Meola S; Laboratory Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Pascale'-IRCCS, 80131 Naples, Italy., Marone S; Laboratory Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Pascale'-IRCCS, 80131 Naples, Italy., Pierro G; Laboratory Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Pascale'-IRCCS, 80131 Naples, Italy., Menegozzo S; Medical Direction, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Pascale'-IRCCS, 80131 Naples, Italy., Miscio L; Medical Direction, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Pascale'-IRCCS, 80131 Naples, Italy., Perri F; Head and Neck Medical and Experimental Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Pascale'-IRCCS, 80131 Naples, Italy., Rainisio M; AbaNovus srl, 18038 Sanremo, Italy., Bianchi AAM; Directorate-General for Management, IRCCS Fondazione G. Pascale, 80131 Naples, Italy., Cavalcanti E; Laboratory Medicine Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Pascale'-IRCCS, 80131 Naples, Italy., Cascella M; Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, 80131 Naples, Italy., Celentano E; Epidemiology and Biostatistics Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 'Fondazione Pascale'-IRCCS, 80131 Naples, Italy.
Jazyk:	angličtina
Zdroj:	Healthcare (Basel, Switzerland) [Healthcare (Basel)] 2022 Jan 20; Vol. 10 (2). Date of Electronic Publication: 2022 Jan 20.
DOI:	10.3390/healthcare10020205
Abstrakt:	Background: From the beginning of 2020, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) quickly spread worldwide, becoming the main problem for the healthcare systems. Healthcare workers (HCWs) are at higher risk of infection and can be a dangerous vehicle for the spread of the virus. Furthermore, cancer patients (CPs) are a vulnerable population, with an increased risk of developing severe and lethal forms of Coronavirus Disease 19 (COVID-19). Therefore, at the National Cancer Institute of Naples, where only cancer patients are treated, a surveillance program aimed to prevent the hospital access of SARS-CoV-2 positive subjects (HCWs and CPs) was implemented. The study aims to describe the results of the monitoring activity for the SARS-CoV-2 spread among HCWs and CPs, from March 2020 to March 2021. Methods: This surveillance program included a periodic sampling through nasopharyngeal molecular swabs for SARS-CoV-2 (Real-Time Polymerase Chain Reaction, RT-PCR). CPs were submitted to the molecular test at least 48 h before hospital admission. Survival analysis and multiple logistic regression models were performed among HCWs and CPs to assess the main SARS-CoV-2 risk factors. Results: The percentages of HCWs tested with RT-PCR for the detection of SARS-CoV-2, according to the first and the second wave, were 79.7% and 91.7%, respectively, while the percentages for the CPs were 24.6% and 39.6%. SARS-CoV-2 was detected in 20 (1.7%) HCWs of the 1204 subjects tested during the first wave, and in 127 (9.2%) of 1385 subjects tested in the second wave ( p < 0.001); among CPs, the prevalence of patients tested varied from 100 (4.6%) during the first wave to 168 (4.9%) during the second wave ( p = 0.8). The multivariate logistic analysis provided a significant OR for nurses (OR = 2.24, 95% CI 1.23-4.08, p < 0.001) compared to research, administrative staff, and other job titles. Conclusions: Our findings show that the positivity rate between the two waves in the HCWs increased over time but not in the CPs; therefore, the importance of adopting stringent measures to contain the shock wave of SARS-CoV-2 infection in the hospital setting was essential. Among HCWs, nurses are more exposed to contagion and patients who needed continuity in oncological care for diseases other than COVID-19, such as suspected cancer.
Databáze:	MEDLINE
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