Early Markers of Cardiovascular Disease Associated with Clinical Data and Autosomal Ancestry in Patients with Type 1 Diabetes: A Cross-Sectional Study in an Admixed Brazilian Population.

Autor:	Reis RMDF; Graduate Program in Adult Health (PPGSAD), Federal University of Maranhão-UFMA, Av. dos Portugueses, São Luís 65085-580, Brazil., Azulay RSS; Service of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA/EBSERH), Rua Barão de Itapary, 227-Centro, São Luís 65020-070, Brazil., Tavares MDG; Service of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA/EBSERH), Rua Barão de Itapary, 227-Centro, São Luís 65020-070, Brazil., Nascimento GC; Service of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA/EBSERH), Rua Barão de Itapary, 227-Centro, São Luís 65020-070, Brazil., Damianse SDSP; Service of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA/EBSERH), Rua Barão de Itapary, 227-Centro, São Luís 65020-070, Brazil., Rocha VCC; Service of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA/EBSERH), Rua Barão de Itapary, 227-Centro, São Luís 65020-070, Brazil., Almeida AG; Research Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), São Luís 65020-070, Brazil., Lago DCF; Service of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA/EBSERH), Rua Barão de Itapary, 227-Centro, São Luís 65020-070, Brazil., Rodrigues V; Research Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), São Luís 65020-070, Brazil., Magalhães M; Graduate Program in Adult Health (PPGSAD), Federal University of Maranhão-UFMA, Av. dos Portugueses, São Luís 65085-580, Brazil., Sobral CS; Service of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA/EBSERH), Rua Barão de Itapary, 227-Centro, São Luís 65020-070, Brazil., Parente C; Service of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA/EBSERH), Rua Barão de Itapary, 227-Centro, São Luís 65020-070, Brazil., França J; Service of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA/EBSERH), Rua Barão de Itapary, 227-Centro, São Luís 65020-070, Brazil., Ribeiro J; Research Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), São Luís 65020-070, Brazil., Ferraz PCD; Research Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), São Luís 65020-070, Brazil., Junior CAA; Research Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), São Luís 65020-070, Brazil., Silva DA; DNA Diagnostic Laboratory (LDD), Rio de Janeiro State University (UERJ), R. São Francisco Xavier, Rio de Janeiro 20550-013, Brazil., Gomes MB; Diabetes Unit, State University of Rio de Janeiro (UERJ), R. São Francisco Xavier, Rio de Janeiro 20550-013, Brazil., Faria MDS; Graduate Program in Adult Health (PPGSAD), Federal University of Maranhão-UFMA, Av. dos Portugueses, São Luís 65085-580, Brazil.
Jazyk:	angličtina
Zdroj:	Genes [Genes (Basel)] 2022 Feb 21; Vol. 13 (2). Date of Electronic Publication: 2022 Feb 21.
DOI:	10.3390/genes13020389
Abstrakt:	Patients with type 1 diabetes (T1D) have a higher risk of developing cardiovascular disease (CVD), which is a major cause of death in this population. This study investigates early markers of CVD associated with clinical data and autosomal ancestry in T1D patients from an admixed Brazilian population. A cross-sectional study was conducted with 99 T1D patients. The mean age of the study sample was 27.6 years and the mean duration of T1D was 14.4 years. The frequencies of abnormalities of the early markers of CVD were 19.6% in the ankle-brachial index (ABI), 4.1% in the coronary artery calcium score (CACS), and 5% in the carotid Doppler. A significant percentage of agreement was observed for the comparison of the frequency of abnormalities between CACS and carotid Doppler (92.2%, p = 0.041). There was no significant association between the level of autosomal ancestry proportions and early markers of CVD. The ABI was useful in the early identification of CVD in asymptomatic young patients with T1D and with a short duration of disease. Although CACS and carotid Doppler are non-invasive tests, carotid Doppler is more cost-effective, and both have limitations in screening for CVD in young patients with a short duration of T1D. We did not find a statistically significant relationship between autosomal ancestry proportions and early CVD markers in an admixed Brazilian population.
Databáze:	MEDLINE
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