Agent-Based Modeling of Autosomal Recessive Deafness 1A (DFNB1A) Prevalence with Regard to Intensity of Selection Pressure in Isolated Human Population.

Autor:	Romanov GP; Laboratory of Molecular Biology, M. K. Ammosov North-Eastern Federal University, Kulakovskogo 46, 677010 Yakutsk, Russia.; Laboratory of Molecular Genetics, Yakut Science Centre of Complex Medical Problems, Yaroslavskogo 6/3, 677000 Yakutsk, Russia., Smirnova AA; Sector for Computer Analysis and Modeling of Biological Systems, Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentyeva 10, 630090 Novosibirsk, Russia., Zamyatin VI; Sector for Computer Analysis and Modeling of Biological Systems, Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentyeva 10, 630090 Novosibirsk, Russia., Mukhin AM; Sector for Computer Analysis and Modeling of Biological Systems, Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentyeva 10, 630090 Novosibirsk, Russia., Kazantsev FV; Sector for Computer Analysis and Modeling of Biological Systems, Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentyeva 10, 630090 Novosibirsk, Russia.; Novosibirsk State University, Pirogova 1, 630090 Novosibirsk, Russia., Pshennikova VG; Laboratory of Molecular Genetics, Yakut Science Centre of Complex Medical Problems, Yaroslavskogo 6/3, 677000 Yakutsk, Russia., Teryutin FM; Laboratory of Molecular Biology, M. K. Ammosov North-Eastern Federal University, Kulakovskogo 46, 677010 Yakutsk, Russia.; Laboratory of Molecular Genetics, Yakut Science Centre of Complex Medical Problems, Yaroslavskogo 6/3, 677000 Yakutsk, Russia., Solovyev AV; Laboratory of Molecular Biology, M. K. Ammosov North-Eastern Federal University, Kulakovskogo 46, 677010 Yakutsk, Russia., Fedorova SA; Laboratory of Molecular Biology, M. K. Ammosov North-Eastern Federal University, Kulakovskogo 46, 677010 Yakutsk, Russia.; Laboratory of Molecular Genetics, Yakut Science Centre of Complex Medical Problems, Yaroslavskogo 6/3, 677000 Yakutsk, Russia., Posukh OL; Novosibirsk State University, Pirogova 1, 630090 Novosibirsk, Russia.; Laboratory of Human Molecular Genetics, Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentyeva 10, 630090 Novosibirsk, Russia., Lashin SA; Sector for Computer Analysis and Modeling of Biological Systems, Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentyeva 10, 630090 Novosibirsk, Russia.; Novosibirsk State University, Pirogova 1, 630090 Novosibirsk, Russia., Barashkov NA; Laboratory of Molecular Biology, M. K. Ammosov North-Eastern Federal University, Kulakovskogo 46, 677010 Yakutsk, Russia.; Laboratory of Molecular Genetics, Yakut Science Centre of Complex Medical Problems, Yaroslavskogo 6/3, 677000 Yakutsk, Russia.
Jazyk:	angličtina
Zdroj:	Biology [Biology (Basel)] 2022 Feb 07; Vol. 11 (2). Date of Electronic Publication: 2022 Feb 07.
DOI:	10.3390/biology11020257
Abstrakt:	An increase in the prevalence of autosomal recessive deafness 1A (DFNB1A) in populations of European descent was shown to be promoted by assortative marriages among deaf people. Assortative marriages became possible with the widespread introduction of sign language, resulting in increased genetic fitness of deaf individuals and, thereby, relaxing selection against deafness. However, the effect of this phenomenon was not previously studied in populations with different genetic structures. We developed an agent-based computer model for the analysis of the spread of DFNB1A. Using this model, we tested the impact of different intensities of selection pressure against deafness in an isolated human population over 400 years. Modeling of the "purifying" selection pressure on deafness ("No deaf mating" scenario) resulted in a decrease in the proportion of deaf individuals and the pathogenic allele frequency. Modeling of the "relaxed" selection ("Assortative mating" scenario) resulted in an increase in the proportion of deaf individuals in the first four generations, which then quickly plateaued with a subsequent decline and a decrease in the pathogenic allele frequency. The results of neutral selection pressure modeling ("Random mating" scenario) showed no significant changes in the proportion of deaf individuals or the pathogenic allele frequency after 400 years.
Databáze:	MEDLINE
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