PCOS: A Chronic Disease That Fails to Produce Adequately Specialized Pro-Resolving Lipid Mediators (SPMs).

Autor:	Regidor PA; Exeltis Healthcare, Adalperostr. 84, 85737 Ismaning, Germany.; OTC Chemo, Manuel Pombo Angulo 28-4th Floor, 28050 Madrid, Spain., de la Rosa X; Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, 60 Fenwood Road Boston, Boston, MA 02115, USA., Müller A; Exeltis Healthcare, Adalperostr. 84, 85737 Ismaning, Germany., Mayr M; Exeltis Healthcare, Adalperostr. 84, 85737 Ismaning, Germany., Gonzalez Santos F; Solutex SA, Avenida de la Transición Espanola 24, 28108 Alcobendas, Spain., Gracia Banzo R; Solutex GC SL, Parque Empresarial Utebo, Avda. Miguel Servet n° 81, 50180 Utebo, Spain., Rizo JM; OTC Chemo, Manuel Pombo Angulo 28-4th Floor, 28050 Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Biomedicines [Biomedicines] 2022 Feb 16; Vol. 10 (2). Date of Electronic Publication: 2022 Feb 16.
DOI:	10.3390/biomedicines10020456
Abstrakt:	Introduction: Polycystic ovary syndrome (PCOS) is an endocrinological disorder that affects 5-15% of women of their reproductive age and is a frequent cause of infertility. Major symptoms include hyperandrogenism, ovulatory dysfunction, and often obesity and/or insulin resistance. PCOS also represents a state of chronic low-grade inflammation that is closely interlinked with the metabolic features. "Classical" pro-inflammatory lipid mediators such as prostaglandins (PG), leukotrienes (LT), or thromboxanes (TX) are derived from arachidonic acid (AA) and are crucial for the initial response. Resolution processes are driven by four families of so-called specialized pro-resolving mediators (SPMs): resolvins, maresins, lipoxins, and protectins. The study aimed to establish lipid mediator profiles of PCOS patients compared to healthy women to identify differences in their resolutive and pro-inflammatory lipid parameters. Material and Methods: Fifteen female patients (18-45 years) were diagnosed with PCOS according to Rotterdam criteria, and five healthy women, as a comparator group, were recruited for the study. The main outcome measures were: pro-inflammatory lipid mediators (PG, LT, TX) and their precursor AA, SPMs (resolvins, maresins, protectins, lipoxins), their precursors EPA, DHA, DPA, and their active biosynthesis pathway intermediates (18-HEPE, 17-HDHA, 14-HDHA). Results: The level of pro-inflammatory parameters in serum was significantly higher in PCOS-affected women. The ratio (sum of pro-inflammatory molecules)/(sum of SPMs plus hydroxylated intermediates) reflecting the inflammatory state was significantly lower in the group of healthy women. Conclusion: There is a strong pro-inflammatory state in PCOS patients. Further research will clarify whether supplementation with SPMs or their precursors may improve this state.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu