Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis.

Autor:	García-Mendívil L; Biomedical Signal Interpretation and Computational Simulation Group (BSICoS), Aragón Institute of Engineering Research, University of Zaragoza, Zaragoza 50018, Spain.; BSICoS, IIS Aragón, Zaragoza 50018, Spain., Pérez-Zabalza M; Biomedical Signal Interpretation and Computational Simulation Group (BSICoS), Aragón Institute of Engineering Research, University of Zaragoza, Zaragoza 50018, Spain.; BSICoS, IIS Aragón, Zaragoza 50018, Spain., Mountris K; Biomedical Signal Interpretation and Computational Simulation Group (BSICoS), Aragón Institute of Engineering Research, University of Zaragoza, Zaragoza 50018, Spain.; BSICoS, IIS Aragón, Zaragoza 50018, Spain., Duwé S; Advanced Optical Microscopy Centre, Biomedical Research Institute, Hasselt University, Diepenbeek 3500, Belgium., Smisdom N; Biomedical Research Institute, Hasselt University, Diepenbeek 3500, Belgium., Pérez M; Department of Anatomy, Embryology and Animal Genetics, University of Zaragoza, Zaragoza 50013, Spain.; Instituto Universitario de Investigación Mixto Agroalimentario de Aragón (IA2), University of Zaragoza, Zaragoza 50013, Spain., Luján L; Instituto Universitario de Investigación Mixto Agroalimentario de Aragón (IA2), University of Zaragoza, Zaragoza 50013, Spain.; Department of Animal Pathology, University of Zaragoza, Zaragoza 50013, Spain., Wolfs E; Biomedical Research Institute, Hasselt University, Diepenbeek 3500, Belgium., Driesen RB; Biomedical Research Institute, Hasselt University, Diepenbeek 3500, Belgium., Vallejo-Gil JM; Department of Cardiovascular Surgery, University Hospital Miguel Servet, Zaragoza 50009, Spain., Fresneda-Roldán PC; Department of Cardiovascular Surgery, University Hospital Miguel Servet, Zaragoza 50009, Spain., Fañanás-Mastral J; Department of Cardiovascular Surgery, University Hospital Miguel Servet, Zaragoza 50009, Spain., Vázquez-Sancho M; Department of Cardiovascular Surgery, University Hospital Miguel Servet, Zaragoza 50009, Spain., Matamala-Adell M; Department of Cardiovascular Surgery, University Hospital Miguel Servet, Zaragoza 50009, Spain., Sorribas-Berjón JF; Department of Cardiovascular Surgery, University Hospital Miguel Servet, Zaragoza 50009, Spain., Bellido-Morales JA; Department of Cardiovascular Surgery, University Hospital Miguel Servet, Zaragoza 50009, Spain., Mancebón-Sierra FJ; Department of Cardiovascular Surgery, University Hospital Miguel Servet, Zaragoza 50009, Spain., Vaca-Núñez AS; Department of Cardiovascular Surgery, University Hospital Miguel Servet, Zaragoza 50009, Spain., Ballester-Cuenca C; Department of Cardiovascular Surgery, University Hospital Miguel Servet, Zaragoza 50009, Spain., Oliván-Viguera A; Biomedical Signal Interpretation and Computational Simulation Group (BSICoS), Aragón Institute of Engineering Research, University of Zaragoza, Zaragoza 50018, Spain.; BSICoS, IIS Aragón, Zaragoza 50018, Spain.; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Zaragoza 50018, Spain., Diez E; Institute of Experimental Medicine and Biology of Cuyo (IMBECU), CONICET, Mendoza 5500, Argentina., Ordovás L; Biomedical Signal Interpretation and Computational Simulation Group (BSICoS), Aragón Institute of Engineering Research, University of Zaragoza, Zaragoza 50018, Spain.; BSICoS, IIS Aragón, Zaragoza 50018, Spain.; ARAID Foundation, Zaragoza 50018, Spain., Pueyo E; Biomedical Signal Interpretation and Computational Simulation Group (BSICoS), Aragón Institute of Engineering Research, University of Zaragoza, Zaragoza 50018, Spain.; BSICoS, IIS Aragón, Zaragoza 50018, Spain.; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Zaragoza 50018, Spain.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2022 Jan 29; Vol. 25 (2), pp. 103822. Date of Electronic Publication: 2022 Jan 29 (Print Publication: 2022).
DOI:	10.1016/j.isci.2022.103822
Abstrakt:	Age-related fibrosis in the left ventricle (LV) has been mainly studied in animals by assessing collagen content. Using second-harmonic generation microscopy and image processing, we evaluated amount, aggregation and spatial distribution of LV collagen in young to old pigs, and middle-age and elder living donors. All collagen features increased when comparing adult and old pigs with young ones, but not when comparing adult with old pigs or middle-age with elder individuals. Remarkably, all collagen parameters strongly correlated with lipofuscin, a biological age marker, in humans. By building patient-specific models of human ventricular tissue electrophysiology, we confirmed that amount and organization of fibrosis modulated arrhythmia vulnerability, and that distribution should be accounted for arrhythmia risk assessment. In conclusion, we characterize the age-associated changes in LV collagen and its potential implications for ventricular arrhythmia development. Consistency between pig and human results substantiate the pig as a relevant model of age-related LV collagen dynamics. Competing Interests: The authors declare no competing interests. (© 2022 The Author(s).)
Databáze:	MEDLINE
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