Umbilical Cord Blood Leptin and IL-6 in the Presence of Maternal Diabetes or Chorioamnionitis.

Autor:	Vasilakos LK; Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, United States., Steinbrekera B; Department of Pediatrics, University of South Dakota, Sioux Falls, SD, United States., Santillan DA; Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City, IA, United States., Santillan MK; Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City, IA, United States., Brandt DS; Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City, IA, United States., Dagle D; Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, United States., Roghair RD; Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Feb 07; Vol. 13, pp. 836541. Date of Electronic Publication: 2022 Feb 07 (Print Publication: 2022).
DOI:	10.3389/fendo.2022.836541
Abstrakt:	Diabetes during pregnancy is associated with elevated maternal insulin, leptin and IL-6. Within the placenta, IL-6 can further stimulate leptin production. Despite structural similarities and shared roles in inflammation, leptin and IL-6 have contrasting effects on neurodevelopment, and the relative importance of maternal diabetes or chorioamnionitis on fetal hormone exposure has not been defined. We hypothesized that there would be a positive correlation between IL-6 and leptin with progressively increased levels in pregnancies complicated by maternal diabetes and chorioamnionitis. To test this hypothesis, cord blood samples were obtained from 104 term infants, including 47 exposed to maternal diabetes. Leptin, insulin, and IL-6 were quantified by multiplex assay. Factors independently associated with hormone levels were identified by univariate and multivariate linear regression. Unlike IL-6, leptin and insulin were significantly increased by maternal diabetes. Maternal BMI and birth weight were independent predictors of leptin and insulin with birth weight the strongest predictor of leptin. Clinically diagnosed chorioamnionitis and neonatal sepsis were associated with increased IL-6 but not leptin. Among appropriate for gestational age infants without sepsis, IL-6 and leptin were strongly correlated (R=0.6, P<0.001). In summary, maternal diabetes and birth weight are associated with leptin while chorioamnionitis is associated with IL-6. The constraint of the positive association between leptin and IL-6 to infants without sepsis suggests that the term infant and placenta may have a limited capacity to increase cord blood levels of the neuroprotective hormone leptin in the presence of increased cord blood levels of the potential neurotoxin IL-6. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Vasilakos, Steinbrekera, Santillan, Santillan, Brandt, Dagle and Roghair.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu