Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection.

Autor: Pekayvaz K; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany. kami.pekayvaz@med.uni-muenchen.de.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany. kami.pekayvaz@med.uni-muenchen.de., Leunig A; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany., Kaiser R; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany., Joppich M; Department of Informatics, Ludwig-Maximilian Universität München, Munich, Germany., Brambs S; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany., Janjic A; Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians University Munich, Munich, Germany., Popp O; Max Delbrück Center for Molecular Medicine (MDC) and Berlin Institute of Health (BIH), Berlin, Germany., Nixdorf D; Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.; Department of Medicine III, University Hospital, LMU Munich, Munich, Germany., Fumagalli V; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.; Vita-Salute San Raffaele University, 20132, Milan, Italy., Schmidt N; Helmholtz Institute for RNA-based Infection Research, Helmholtz-Center for Infection Research, Würzburg, Germany., Polewka V; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany., Anjum A; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany., Knottenberg V; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany., Eivers L; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany., Wange LE; Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians University Munich, Munich, Germany., Gold C; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany., Kirchner M; Max Delbrück Center for Molecular Medicine (MDC) and Berlin Institute of Health (BIH), Berlin, Germany., Muenchhoff M; Max von Pettenkofer Institute & GeneCenter, Virology, Faculty of Medicine, LMU München, Munich, Germany.; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany.; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU Munich, Munich, Germany., Hellmuth JC; Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU Munich, Munich, Germany., Scherer C; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU Munich, Munich, Germany., Rubio-Acero R; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany.; Division of Infectious Diseases and Tropical Medicine, University Hospital Ludwig-Maximilian University Munich, Munich, Germany., Eser T; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany.; Division of Infectious Diseases and Tropical Medicine, University Hospital Ludwig-Maximilian University Munich, Munich, Germany., Deák F; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany.; Division of Infectious Diseases and Tropical Medicine, University Hospital Ludwig-Maximilian University Munich, Munich, Germany., Puchinger K; Division of Infectious Diseases and Tropical Medicine, University Hospital Ludwig-Maximilian University Munich, Munich, Germany., Kuhl N; Gene Center and Department of Biochemistry, University Hospital Ludwig-Maximilian University Munich, Munich, Germany.; Department of Medicine II, University Hospital, LMU Munich, Munich, Germany., Linder A; Gene Center and Department of Biochemistry, University Hospital Ludwig-Maximilian University Munich, Munich, Germany.; Department of Medicine II, University Hospital, LMU Munich, Munich, Germany., Saar K; Max Delbrück Center for Molecular Medicine (MDC) and Berlin Institute of Health (BIH), Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 13347, Berlin, Germany., Tomas L; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany., Schulz C; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany., Wieser A; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany.; Division of Infectious Diseases and Tropical Medicine, University Hospital Ludwig-Maximilian University Munich, Munich, Germany., Enard W; Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians University Munich, Munich, Germany., Kroidl I; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany.; Division of Infectious Diseases and Tropical Medicine, University Hospital Ludwig-Maximilian University Munich, Munich, Germany., Geldmacher C; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany.; Division of Infectious Diseases and Tropical Medicine, University Hospital Ludwig-Maximilian University Munich, Munich, Germany., von Bergwelt-Baildon M; Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU Munich, Munich, Germany., Keppler OT; Max von Pettenkofer Institute & GeneCenter, Virology, Faculty of Medicine, LMU München, Munich, Germany.; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany.; COVID-19 Registry of the LMU Munich (CORKUM), University Hospital, LMU Munich, Munich, Germany., Munschauer M; Helmholtz Institute for RNA-based Infection Research, Helmholtz-Center for Infection Research, Würzburg, Germany., Iannacone M; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.; Vita-Salute San Raffaele University, 20132, Milan, Italy.; Experimental Imaging Centre, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy., Zimmer R; Department of Informatics, Ludwig-Maximilian Universität München, Munich, Germany., Mertins P; Max Delbrück Center for Molecular Medicine (MDC) and Berlin Institute of Health (BIH), Berlin, Germany., Hubner N; Max Delbrück Center for Molecular Medicine (MDC) and Berlin Institute of Health (BIH), Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 13347, Berlin, Germany., Hoelscher M; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany.; Division of Infectious Diseases and Tropical Medicine, University Hospital Ludwig-Maximilian University Munich, Munich, Germany., Massberg S; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany., Stark K; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany. konstantin.stark@med.uni-muenchen.de.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany. konstantin.stark@med.uni-muenchen.de., Nicolai L; Department of Medicine I, University Hospital, LMU Munich, Munich, Germany. leo.nicolai@med.uni-muenchen.de.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany. leo.nicolai@med.uni-muenchen.de.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2022 Feb 23; Vol. 13 (1), pp. 1018. Date of Electronic Publication: 2022 Feb 23.
DOI: 10.1038/s41467-022-28508-0
Abstrakt: The antiviral immune response to SARS-CoV-2 infection can limit viral spread and prevent development of pneumonic COVID-19. However, the protective immunological response associated with successful viral containment in the upper airways remains unclear. Here, we combine a multi-omics approach with longitudinal sampling to reveal temporally resolved protective immune signatures in non-pneumonic and ambulatory SARS-CoV-2 infected patients and associate specific immune trajectories with upper airway viral containment. We see a distinct systemic rather than local immune state associated with viral containment, characterized by interferon stimulated gene (ISG) upregulation across circulating immune cell subsets in non-pneumonic SARS-CoV2 infection. We report reduced cytotoxic potential of Natural Killer (NK) and T cells, and an immune-modulatory monocyte phenotype associated with protective immunity in COVID-19. Together, we show protective immune trajectories in SARS-CoV2 infection, which have important implications for patient prognosis and the development of immunomodulatory therapies.
(© 2022. The Author(s).)
Databáze: MEDLINE
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