Autophagy: The "Pac-Man" within Us-Ally or Adversary?

Autor: Pandarathodiyil AK; Faculty of Dentistry, SEGi University, Petaling Jaya, Selangor, Malaysia, e-mail: anithakrishnan@segi.edu.my., Vijayan SP; Department of Prosthodontics and Restorative Dentistry, School of Dentistry, College of Medicine and Health Sciences, University of Rwanda, Remera Campus, Kigali, Rwanda., Ramanathan A; Department of Oral Maxillofacial Clinical Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia; Oral Cancer Research and Coordinating Centre, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia., Rao RS; Department of Oral Pathology, Faculty of Dental Sciences, MS Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India., Patil S; Department of Maxillofacial Surgery and Diagnostic Science, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
Jazyk: angličtina
Zdroj: The journal of contemporary dental practice [J Contemp Dent Pract] 2021 Oct 01; Vol. 22 (10), pp. 1079-1081. Date of Electronic Publication: 2021 Oct 01.
Abstrakt: Autophagy, first described by the Belgian biochemist Christian De Duve in 1963, is derived from the Greek word "autóphagos," which means "self-devouring." It is a cellular homeostatic process in which the body rids itself of flawed or damaged cells and other defective cellular organelles. 1 The implication of defective autophagy in various human diseases has been well documented. The vital importance of autophagy is underscored by the fact that robust cellular health and function are intricately linked with it.
Databáze: MEDLINE