| Autor: |
Awokola BI; Centre for Health Informatics, Computing & Statistics (CHICAS), Lancaster Medical School, Lancaster University, Bailrigg, Lancaster, UK, Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK, Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia., Amusa GA; Department of Internal Medicine, Jos University Teaching Hospital, Jos, Nigeria, Department of Medicine, University of Jos, Jos, Nigeria., Jewell CP; Centre for Health Informatics, Computing & Statistics (CHICAS), Lancaster Medical School, Lancaster University, Bailrigg, Lancaster, UK., Okello G; University of Cambridge Institute for Sustainability Leadership, Cambridge, UK, African Centre for Clean Air, Kampala, Uganda., Stobrink M; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK., Finney LJ; COPD Research Group, Imperial College, London, UK., Mohammed N; Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia., Erhart A; Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Fajara, The Gambia., Mortimer KJ; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK. |
| Abstrakt: |
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide and an important cause of death in sub-Saharan Africa (SSA). We conducted a systematic review and meta-analysis on the prevalence of and risk factors for COPD in SSA. METHODS: We conducted a protocol-driven systematic literature search in MEDLINE, EMBASE, CINAHL and Global Health, supplemented by a manual search of the abstracts from thoracic conference proceedings from 2017 to 2020. We did a meta-analysis of COPD prevalence and its association with current smoking. RESULTS: We identified 831 titles, of which 27 were eligible for inclusion in the review and meta-analysis. The population prevalence of COPD ranged from 1.7% to 24.8% (pooled prevalence: 8%, 95% CI 6-11). An increased prevalence of COPD was associated with increasing age, smoking and biomass smoke exposure. The pooled odds ratio for the effect of current smoking (vs. never smoked) on COPD was 2.20 (95% CI 1.62-2.99). CONCLUSION: COPD causes morbidity and mortality in adults in SSA. Smoking is an important risk factor for COPD in SSA, and this exposure needs to be reduced through the combined efforts of clinicians, researchers and policymakers to address this debilitating and preventable lung disease. |
