Toxoplasmosis in a free-ranging hairy dwarf porcupine (Sphiggurus spinosus) with a potential novel genotype.

Autor: Santos ALMD; Laboratory of Wildlife Comparative Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, São Paulo, Brazil.; Pathology Center, Adolfo Lutz Institute, São Paulo, São Paulo, Brazil., Navas-Suárez PE; Laboratory of Wildlife Comparative Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, São Paulo, Brazil.; Pathology Center, Adolfo Lutz Institute, São Paulo, São Paulo, Brazil., Guerra JM; Pathology Center, Adolfo Lutz Institute, São Paulo, São Paulo, Brazil., Ervedosa TB; Pathology Center, Adolfo Lutz Institute, São Paulo, São Paulo, Brazil., Rivas L; Wildlife Division, Centro de Manejo e Conservação de Animais Silvestres, CEMACAS, São Paulo, São Paulo, Brazil., Joppert A; Wildlife Division, Centro de Manejo e Conservação de Animais Silvestres, CEMACAS, São Paulo, São Paulo, Brazil., Machado EF; Laboratory of Wildlife Comparative Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, São Paulo, Brazil.; Pathology Center, Adolfo Lutz Institute, São Paulo, São Paulo, Brazil., Ressio RA; Pathology Center, Adolfo Lutz Institute, São Paulo, São Paulo, Brazil., Jesus IP; Pathology Center, Adolfo Lutz Institute, São Paulo, São Paulo, Brazil., Carvalho J; Pathology Center, Adolfo Lutz Institute, São Paulo, São Paulo, Brazil., Matsumoto PSS; Pathology Center, Adolfo Lutz Institute, São Paulo, São Paulo, Brazil., Figueiredo KB; Pathology Center, Adolfo Lutz Institute, São Paulo, São Paulo, Brazil., Catão-Dias JL; Laboratory of Wildlife Comparative Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, São Paulo, Brazil., Fernandes NCCA; Laboratory of Wildlife Comparative Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, São Paulo, Brazil.; Pathology Center, Adolfo Lutz Institute, São Paulo, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Transboundary and emerging diseases [Transbound Emerg Dis] 2022 Sep; Vol. 69 (5), pp. e3225-e3230. Date of Electronic Publication: 2022 Mar 03.
DOI: 10.1111/tbed.14487
Abstrakt: Toxoplasmosis is a zoonotic disease caused by the ubiquitous coccidia Toxoplasma gondii. Rodents play an important role in maintaining its life cycle, as they are one of the main diet sources for felids (wild and domestic), the unique definitive hosts. However, reports of toxoplasmosis in porcupines (Order Rodentia) are uncommon, with gaps concerning its pathophysiology. South America is the continent with the greatest genetic diversity of rodents and T. gondii. A free-ranging hairy dwarf porcupine was admitted to a wildlife rescue centre with a history of trauma. During rehabilitation, the animal presented neurological symptoms (sporadic episodes of hind limbs paresis) and died 5 months later. The main findings during necropsy were brain congestion and severe incisor overgrowth associated with maxillary perforation. The histopathological exam showed moderate encephalitis, with variable-sized round cysts, positive for PAS stain and immunohistochemistry for T. gondii. Additionally, two cysts were observed in the medulla of the adrenal gland. Molecular techniques were performed to characterize the parasite load by qPCR (Cq = 30) and the genotype by PCR-RFLP with 11 markers, which revealed a potential new genotype. This case adds to the body of knowledge in comparative pathology of Neotropical Rodentia and reports a new potential genotype circulating in South America.
(© 2022 Wiley-VCH GmbH.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje