Bimetallic Nanocatalysts Immobilized in Nanoporous Hydrogels for Long-Term Robust Continuous Glucose Monitoring of Smart Contact Lens.

Autor: Kim SK; Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 37673, Republic of Korea., Lee GH; Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 37673, Republic of Korea., Jeon C; Department of Electrical Enginnering, POSTECH, 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 37673, Republic of Korea., Han HH; Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 37673, Republic of Korea., Kim SJ; Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 37673, Republic of Korea., Mok JW; Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, Collage of Medicine, The Catholic University of Korea, 505, Banpo-dong, Seocho-gu, Seoul, 06591, Korea., Joo CK; Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, Collage of Medicine, The Catholic University of Korea, 505, Banpo-dong, Seocho-gu, Seoul, 06591, Korea., Shin S; PHI BIOMED Co., 168, Yeoksam-ro, Gangnam-gu, Seoul, 06248, Korea., Sim JY; Department of Electrical Enginnering, POSTECH, 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 37673, Republic of Korea., Myung D; Department of Chemical Engineering, Stanford University, 443 Via Ortega, Stanford, CA, 94305, USA.; Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA, 94303, USA., Bao Z; Department of Chemical Engineering, Stanford University, 443 Via Ortega, Stanford, CA, 94305, USA., Hahn SK; Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 37673, Republic of Korea.; PHI BIOMED Co., 168, Yeoksam-ro, Gangnam-gu, Seoul, 06248, Korea.
Jazyk: angličtina
Zdroj: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2022 May; Vol. 34 (18), pp. e2110536. Date of Electronic Publication: 2022 Mar 13.
DOI: 10.1002/adma.202110536
Abstrakt: Smart contact lenses for continuous glucose monitoring (CGM) have great potential for huge clinical impact. To date, their development has been limited by challenges in accurate detection of glucose without hysteresis for tear glucose monitoring to track the blood glucose levels. Here, long-term robust CGM in diabetic rabbits is demonstrated by using bimetallic nanocatalysts immobilized in nanoporous hydrogels in smart contact lenses. After redox reaction of glucose oxidase, the nanocatalysts facilitate rapid decomposition of hydrogen peroxide and nanoparticle-mediated charge transfer with drastically improved diffusion via rapid swelling of nanoporous hydrogels. The ocular glucose sensors result in high sensitivity, fast response time, low detection limit, low hysteresis, and rapid sensor warming-up time. In diabetic rabbits, smart contact lens can detect tear glucose levels consistent with blood glucose levels measured by a glucometer and a CGM device, reflecting rapid concentration changes without hysteresis. The CGM in a human demonstrates the feasibility of smart contact lenses for further clinical applications.
(© 2022 Wiley-VCH GmbH.)
Databáze: MEDLINE
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