Borneol reduces sympathetic vasomotor hyperactivity and restores depressed baroreflex sensitivity in rats with renovascular hypertension.

Autor: Luz MS; Centro de Biotecnologia, Universidade Federal da Paraíba, João Pessoa, PB, Brasil., Gadelha DDA; Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, Brasil., Andrade KJS; Centro de Ciências Médicas, Universidade Federal da Paraíba, João Pessoa, PB, Brasil., Travassos RA; Centro de Biotecnologia, Universidade Federal da Paraíba, João Pessoa, PB, Brasil., Ribeiro JD; Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, Brasil., Carvalho-Galvão A; Centro de Biotecnologia, Universidade Federal da Paraíba, João Pessoa, PB, Brasil., Cruz JC; Centro de Biotecnologia, Universidade Federal da Paraíba, João Pessoa, PB, Brasil., Balarini CM; Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, Brasil., Braga VA; Centro de Biotecnologia, Universidade Federal da Paraíba, João Pessoa, PB, Brasil., França-Falcão MS; Centro de Biotecnologia, Universidade Federal da Paraíba, João Pessoa, PB, Brasil. francasilva@cbiotec.ufpb.br.
Jazyk: angličtina
Zdroj: Hypertension research : official journal of the Japanese Society of Hypertension [Hypertens Res] 2022 May; Vol. 45 (5), pp. 802-813. Date of Electronic Publication: 2022 Feb 22.
DOI: 10.1038/s41440-022-00868-6
Abstrakt: Borneol is a bicyclic monoterpene that has long been used in traditional Chinese medicine to increase blood-brain barrier permeability and has shown promising cardiovascular effects. The present study aimed to evaluate the effect of borneol on vascular tone, blood pressure, autonomic function, and baroreflex sensitivity in normotensive and hypertensive rats. A combination of in vitro and in vivo assays was performed in 2-kidneys-1-clip hypertensive rats (2K1C) and their controls (sham). We assessed the in vivo effect of oral treatment with borneol on blood pressure, heart rate, autonomic function, and baroreflex sensitivity in sham and 2K1C rats. Additionally, the vasorelaxant effect of borneol in the superior mesenteric artery isolated from rats and its mechanism of action were evaluated. Oral administration of borneol (125 mg/kg/day) reduced blood pressure, sympathetic vasomotor hyperactivity, and serum oxidative stress and improved baroreflex sensitivity in 2K1C rats. In vessel preparations, borneol induced endothelium-independent vasodilatation after precontraction with phenylephrine or KCl (60 mM). There was no difference in the vascular effect induced by borneol in either the 2K1C or the sham group. In addition, borneol antagonized the contractions induced by CaCl 2 and reversed (S)-(-)-Bay K 8644-induced contraction. These data suggest that borneol presents antihypertensive effects in 2K1C rats, which is associated with its ability to improve autonomic impairment and baroreflex dysfunction. The borneol-induced relaxation in the superior mesenteric artery involves L-type Ca 2+ channel blockade. This vascular action associated with the antioxidant effect induced by borneol may be responsible, at least in part, for the in vivo effects induced by this monoterpene.
(© 2022. The Author(s), under exclusive licence to The Japanese Society of Hypertension.)
Databáze: MEDLINE
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