Organic electrochemical neurons and synapses with ion mediated spiking.

Autor: Harikesh PC; Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden., Yang CY; Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden., Tu D; Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden., Gerasimov JY; Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden., Dar AM; Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden., Armada-Moreira A; Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden., Massetti M; Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden., Kroon R; Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden., Bliman D; Department of Chemistry and Molecular Biology, University of Gothenburg, SE-412 96, Gothenburg, Sweden., Olsson R; Department of Chemistry and Molecular Biology, University of Gothenburg, SE-412 96, Gothenburg, Sweden.; Chemical Biology and Therapeutics, Department of Experimental Medical Science, Lund University, SE-221 84, Lund, Sweden., Stavrinidou E; Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden.; Wallenberg Wood Science Center, Linköping University, SE-601 74, Norrköping, Sweden., Berggren M; Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden.; Wallenberg Wood Science Center, Linköping University, SE-601 74, Norrköping, Sweden.; n-Ink AB, Teknikringen 7, SE-583 30, Linköping, Sweden., Fabiano S; Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74, Norrköping, Sweden. simone.fabiano@liu.se.; Wallenberg Wood Science Center, Linköping University, SE-601 74, Norrköping, Sweden. simone.fabiano@liu.se.; n-Ink AB, Teknikringen 7, SE-583 30, Linköping, Sweden. simone.fabiano@liu.se.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2022 Feb 22; Vol. 13 (1), pp. 901. Date of Electronic Publication: 2022 Feb 22.
DOI: 10.1038/s41467-022-28483-6
Abstrakt: Future brain-machine interfaces, prosthetics, and intelligent soft robotics will require integrating artificial neuromorphic devices with biological systems. Due to their poor biocompatibility, circuit complexity, low energy efficiency, and operating principles fundamentally different from the ion signal modulation of biology, traditional Silicon-based neuromorphic implementations have limited bio-integration potential. Here, we report the first organic electrochemical neurons (OECNs) with ion-modulated spiking, based on all-printed complementary organic electrochemical transistors. We demonstrate facile bio-integration of OECNs with Venus Flytrap (Dionaea muscipula) to induce lobe closure upon input stimuli. The OECNs can also be integrated with all-printed organic electrochemical synapses (OECSs), exhibiting short-term plasticity with paired-pulse facilitation and long-term plasticity with retention >1000 s, facilitating Hebbian learning. These soft and flexible OECNs operate below 0.6 V and respond to multiple stimuli, defining a new vista for localized artificial neuronal systems possible to integrate with bio-signaling systems of plants, invertebrates, and vertebrates.
(© 2022. The Author(s).)
Databáze: MEDLINE
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