Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells.
| Autor: | Burgess HM; Department of Microbial Sciences, School of Biosciences and Medicine, University of Surrey, Guildford GU2 7XH, United Kingdom., Vink EI; Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA., Mohr I; Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA.; Laura and Isaac Perlmutter Cancer Institute, New York University School of Medicine, New York, New York 10016, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Genes & development [Genes Dev] 2022 Feb 01; Vol. 36 (3-4), pp. 108-132. |
| DOI: | 10.1101/gad.349276.121 |
| Abstrakt: | With their categorical requirement for host ribosomes to translate mRNA, viruses provide a wealth of genetically tractable models to investigate how gene expression is remodeled post-transcriptionally by infection-triggered biological stress. By co-opting and subverting cellular pathways that control mRNA decay, modification, and translation, the global landscape of post-transcriptional processes is swiftly reshaped by virus-encoded factors. Concurrent host cell-intrinsic countermeasures likewise conscript post-transcriptional strategies to mobilize critical innate immune defenses. Here we review strategies and mechanisms that control mRNA decay, modification, and translation in animal virus-infected cells. Besides settling infection outcomes, post-transcriptional gene regulation in virus-infected cells epitomizes fundamental physiological stress responses in health and disease. (© 2022 Burgess et al.; Published by Cold Spring Harbor Laboratory Press.) |
| Databáze: | MEDLINE |
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