The regulatory role of autophagy-related miRNAs in lung cancer drug resistance.

Autor: Shahverdi M; Medical Biotechnology Research Center, Arak University of Medical Sciences, Arak, Iran., Hajiasgharzadeh K; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Sorkhabi AD; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran., Jafarlou M; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Shojaee M; Department of Clinical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Jalili Tabrizi N; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Alizadeh N; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Santarpia M; Medical Oncology Unit, Department of Human Pathology 'G. Barresi', University of Messina, Messina, Italy., Brunetti O; Medical oncology unit, IRCCS Istituto Tumori 'Giovanni Paolo II' of Bari, Bari, Italy., Safarpour H; Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran., Silvestris N; Medical oncology unit, IRCCS Istituto Tumori 'Giovanni Paolo II' of Bari, Bari, Italy; Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari, Bari, Italy. Electronic address: n.silvestris@oncologico.bari.it., Baradaran B; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: baradaranb@tbzmed.ac.ir.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Apr; Vol. 148, pp. 112735. Date of Electronic Publication: 2022 Feb 19.
DOI: 10.1016/j.biopha.2022.112735
Abstrakt: Autophagy is conserved cellular machinery that degrades un-usable proteins and cellular components and has a crucial role in the pathogenesis and drug resistance of various diseases such as lung cancer (LC). Multiple types of endogenous molecules (i.e. miRNAs) have been found to regulate multiple biological processes, such as autophagy. Dysfunction of these molecules is associated with the onset and progression of a variety of human malignancies. Several studies had shown that some miRNAs could mediate autophagy activity in LC cells, which would affect drug resistance as a major problem in LC therapy. Therefore, identifying the underlying molecular targets of miRNAs and their function in autophagy pathways could develop new treatment interventions for LC patients. In this review, we will summarize the interplay between miRNAs, autophagy, and drug resistance of LC patients, as well as the genes and molecular pathways that are involved.
(Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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