The importance of laboratory parameters of the lipid transport system and adipose tissue hormones in assessing the course of chronic.

Autor:	Roytman AP; Federal State Budgetary Educational Institution of Additional Professional Education «Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation»., Sedova NA; Federal State Budgetary Educational Institution of Additional Professional Education «Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation».; State Budgetary Healthcare Institution «Consultative and Diagnostic Center No. 2 of the Moscow City Health Department»., Ivanova EA; State Budgetary Healthcare Institution «S.P. Botkin City Clinical Hospital of the Moscow City Health Department»., Godkov MA; Federal State Budgetary Educational Institution of Additional Professional Education «Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation».; State Budgetary Healthcare Institution «N.V. Sklifosovsky Research Institute of Emergency Medicine of the Moscow Department of Healthcare».
Jazyk:	angličtina
Zdroj:	Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2022 Feb 23; Vol. 67 (2), pp. 85-90.
DOI:	10.51620/0869-2084-2022-67-2-85-90
Abstrakt:	The main manifestations of metabolic syndrome (MS) are disorders of carbohydrate and lipid metabolism and their hormonal regulation. The combined nature of metabolic disorders can significantly affect the course and prognosis of CHF in elderly people with metabolic syndrome. To determine the features of the combined effect of metabolic laboratory parameters and biological active factors of adipose tissue in patients with CHF and metabolic syndrome on the course of the disease. A comparison was made between a group of patients with CHF complicated by MS(n=37) and a group of patients with CHF without MS (n=37). The parameters of lipid metabolism (cholesterol CH and lipoproteins LP), the lipid transport system (ApoA1 and ApoB), leptin, adiponectin and resistin and their mutual relations were studied. The ratio of ApoB/ApoAI levels was indicative, which was 0.80±0.32 in patients with CHF without MS, and 1.12±0.46 in patients with CHF with MS (p <0.05). A significant correlation was found between the ratio of ApoB/ApoA1 levels and abdominal obesity (r=0.42, p<0.05), functional class of CHF (r=0.463, p<0.05), LDL-C level (r=0.518, p<0.05), and triglycerides (r=0.476, p<0.05). Also, significant results were obtained for the leptin/adiponectin ratio. For this ratio, 4 ranks were derived depending on the value of the leptin (ng/ml)/adiponectin (mcg/ml) ratio: less than 1 - rank 0 was assigned, with values of the ratio in the range 1 - 3 - rank 1, in the range 3.1 - 6 - rank 2, and above the value 6 - rank 3. Of the 22 patients who had improved CHF at the end of hospitalization, all at the beginning of hospitalization had a rank 0 or 1 ApoB/ApoA1 ratio. Thus, ranking the values of the ratio of ApoB/ApoA1 levels, and especially leptin/adiponectin, can suggest the probability of successful treatment of CHF or the probability of deterioration of the patient's condition, up to a fatal outcome. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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