Host ecology regulates interspecies recombination in bacteria of the genus Campylobacter .

Autor:	Mourkas E; The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom., Yahara K; Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Tokyo, Japan., Bayliss SC; The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom., Calland JK; The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom., Johansson H; Centre for Ecology and Evolution in Microbial Model Systems, Linnaeus University, Kalmar, Sweden., Mageiros L; The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom., Muñoz-Ramirez ZY; Unidad de Investigacion en Enfermedades Infecciosas, UMAE Pediatria, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Futcher G; The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom., Méric G; The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom., Hitchings MD; Swansea University Medical School, Swansea University, Swansea, United Kingdom., Sandoval-Motta S; Unidad de Investigacion en Enfermedades Infecciosas, UMAE Pediatria, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Torres J; Unidad de Investigacion en Enfermedades Infecciosas, UMAE Pediatria, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Jolley KA; Department of Zoology, University of Oxford, Oxford, United Kingdom., Maiden MCJ; Department of Zoology, University of Oxford, Oxford, United Kingdom., Ellström P; Department of Medical Sciences, Zoonosis Science Centre, Uppsala University, Uppsala, Sweden., Waldenström J; Centre for Ecology and Evolution in Microbial Model Systems, Linnaeus University, Kalmar, Sweden., Pascoe B; The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom.; Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand., Sheppard SK; The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom.; Department of Zoology, University of Oxford, Oxford, United Kingdom.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2022 Feb 22; Vol. 11. Date of Electronic Publication: 2022 Feb 22.
DOI:	10.7554/eLife.73552
Abstrakt:	Horizontal gene transfer (HGT) can allow traits that have evolved in one bacterial species to transfer to another. This has potential to rapidly promote new adaptive trajectories such as zoonotic transfer or antimicrobial resistance. However, for this to occur requires gaps to align in barriers to recombination within a given time frame. Chief among these barriers is the physical separation of species with distinct ecologies in separate niches. Within the genus Campylobacter, there are species with divergent ecologies, from rarely isolated single-host specialists to multihost generalist species that are among the most common global causes of human bacterial gastroenteritis. Here, by characterizing these contrasting ecologies, we can quantify HGT among sympatric and allopatric species in natural populations. Analyzing recipient and donor population ancestry among genomes from 30 Campylobacter species, we show that cohabitation in the same host can lead to a six-fold increase in HGT between species. This accounts for up to 30% of all SNPs within a given species and identifies highly recombinogenic genes with functions including host adaptation and antimicrobial resistance. As described in some animal and plant species, ecological factors are a major evolutionary force for speciation in bacteria and changes to the host landscape can promote partial convergence of distinct species through HGT. Competing Interests: EM, KY, SB, JC, HJ, LM, ZM, GF, GM, MH, SS, JT, KJ, MM, PE, JW, BP, SS No competing interests declared (© 2022, Mourkas et al.)
Databáze:	MEDLINE
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