Mapping of Brain Activity in the Analgesia Induced by Ph α 1 β and Morphine.

Autor:	Diniz DM; Department of Neurotransmitters, Santa Casa, Institute of Education and Research, Belo Horizonte, Brazil., Malamut C; Radiobiology Department, Center for the Development of Nuclear Technology, National Commission of Nuclear Energy (CDTN/CNEN), Belo Horizonte, Brazil., Araújo MR; Radiobiology Department, Center for the Development of Nuclear Technology, National Commission of Nuclear Energy (CDTN/CNEN), Belo Horizonte, Brazil., Ferreira AV; Radiobiology Department, Center for the Development of Nuclear Technology, National Commission of Nuclear Energy (CDTN/CNEN), Belo Horizonte, Brazil., Silva JF; Department of Neurotransmitters, Santa Casa, Institute of Education and Research, Belo Horizonte, Brazil., Cordeiro MDN; Department of Biochemistry, Ezequiel Dias Foundation, Belo Horizonte, Brazil., Borges MH; Department of Biochemistry, Ezequiel Dias Foundation, Belo Horizonte, Brazil., Romano Silva MA; Department of Mental Health, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil., Gomez MV; Department of Neurotransmitters, Santa Casa, Institute of Education and Research, Belo Horizonte, Brazil., Castro Junior CJ; Department of Neurotransmitters, Santa Casa, Institute of Education and Research, Belo Horizonte, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in molecular biosciences [Front Mol Biosci] 2022 Feb 04; Vol. 8, pp. 770471. Date of Electronic Publication: 2022 Feb 04 (Print Publication: 2021).
DOI:	10.3389/fmolb.2021.770471
Abstrakt:	Preclinical evidence suggests the potential of Ph α 1 β , a toxin obtained from the venom of spider Phoneutria nigriventer , as a new analgesic drug. Molecular brain imaging techniques have afforded exciting opportunities to examine brain processes in clinical pain conditions. This paper aims to study the brain regions involved in the analgesic effects of Ph α 1 β compared with Morphine, in a model of acute pain induced by formalin in Sprague Dawley rats. We used 18 F-fluorodeoxyglucose as a metabolic radiotracer to perform brain imaging of rats pretreated with Ph α 1 β or Morphine in a model of acute inflammatory pain caused by intraplantar injection of formalin. The rats' hind paw's formalin stimulation resulted in a brain metabolic increase at the bilateral motor cortex, visual cortex, somatosensory cortex, thalamus, and cingulate cortex.In rats treated with Ph α 1 β , selective inhibition of unilateral motor cortex and cingulate cortex was observed. Morphine treatment leads to small and selective inhibition at the bilateral amygdala striatum and accumbens. Our results indicate that the analgesic effect of Ph α 1 β and Morphine possesses a differential profile of central processing in the pain state. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer (RMF) declared a shared affiliation, with one of the authors (MARS) to the handling editor at the time of the review. (Copyright © 2022 Diniz, Malamut, Araújo, Ferreira, Silva, Cordeiro, Borges, Romano Silva, Gomez and Castro Junior.)
Databáze:	MEDLINE
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