Frequency cumulative effect of subthreshold energy laser-activated remote phosphors irradiation on visual function in guinea pigs.

Autor:	Zhang YF; Center of Clinical Aerospace Medicine, Air Force Medical University, Xi'an 710032, Shaanxi Province, China.; The Air Force Hospital from Northern Theater PLA, Shenyang 110092, Liaoning Province, China., Zhou XH; Ophthalmology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China., Cao RD; Center of Clinical Aerospace Medicine, Air Force Medical University, Xi'an 710032, Shaanxi Province, China., Song JB; Basic Medical College, Air Force Medical University, Xi'an 710032, Shaanxi Province, China., Wei DY; Center of Clinical Aerospace Medicine, Air Force Medical University, Xi'an 710032, Shaanxi Province, China., Duan FJ; Department of Aviation Medicine, Air Force Hospital of Southern Theater Command, Guangzhou 510062, Guangdong Province, China., Wang W; Naval Medical Center of PLA, Shanghai 200433, China., Zhang ZM; Center of Clinical Aerospace Medicine, Air Force Medical University, Xi'an 710032, Shaanxi Province, China., Chen T; Center of Clinical Aerospace Medicine, Air Force Medical University, Xi'an 710032, Shaanxi Province, China.; Department of Aviation Medicine, Xijing Hospital, Air Force Medical University, Xi'an 710032, Shaanxi Province, China.
Jazyk:	angličtina
Zdroj:	International journal of ophthalmology [Int J Ophthalmol] 2022 Feb 18; Vol. 15 (2), pp. 213-220. Date of Electronic Publication: 2022 Feb 18 (Print Publication: 2022).
DOI:	10.18240/ijo.2022.02.04
Abstrakt:	Aim: To explore the effects of laser-activated remote phosphors (LARP) on visual function in guinea pigs. Methods: Electroretinogram (ERG) of guinea pigs were observed after LARP irradiation at different frequencies and irradiation times. We evaluated the expression of rhodopsin, β-catenin, connexin36, calretinin, and calbindin in the retina of guinea pigs and measured the density of photoreceptor cells after high-frequency LARP irradiation. Results: After LARP irradiation, the ERG results showed that the amplitude of the dark-adapted 3.0 b-wave of the model eye was lower than that of the control eye after high-frequency irradiation ( P <0.05). The expression of rhodopsin, β-catenin, connexin36, calretinin, and calbindin in the retina of guinea pig declined. Conclusion: There is frequency cumulative damage effect on the retina that relates to LARP illumination frequency. This has significance for staff visual protection policies under LARP lighting conditions. (International Journal of Ophthalmology Press.)
Databáze:	MEDLINE
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