Normal Saline Versus Low Chloride Solutions in Treatment of Diabetic Ketoacidosis: A Systematic Review of Clinical Trials.
| Autor: | Jahangir A; Medicine, Mayo Hospital, Lahore, PAK., Jahangir A; Medicine, Staten Island University Hospital, New York City, USA., Siddiqui FS; Medicine, Northwell Health, New York City, USA., Niazi MRK; Medicine, Northwell Health, New York City, USA., Yousaf F; Medicine, Northwell Health, New York City, USA., Muhammad M; Internal Medicine, Jinnah Hospital, Lahore, Lahore, PAK., Sahra S; Internal Medicine, Northwell Health, New York City, USA., Javed A; Internal Medicine, Northwell Health, New York City, USA., Sharif MA; Medicine, Mayo Hospital, Lahore, PAK., Iqbal QZ; Endocrinology and Diabetes, Ochsner Medical Center, New Orleans, USA., Krzyzak M; Medicine, Northwell Health, New York City, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2022 Jan 17; Vol. 14 (1), pp. e21324. Date of Electronic Publication: 2022 Jan 17 (Print Publication: 2022). |
| DOI: | 10.7759/cureus.21324 |
| Abstrakt: | Traditionally, normal saline solution (NSS) has been the fluid of choice in diabetic ketoacidosis (DKA) patients, but the NSS is an acidic fluid and may lead to the delayed resolution of DKA. A systemic review search was conducted on PubMed, Embase, and Central Cochrane Registry to compare the efficacy of low chloride solutions with normal saline solution in DKA resolution. Randomized clinical trials with normal saline as a control arm and low chloride solutions as an intervention arm were included. Four studies were included in the analysis. The investigated outcomes, including time to resolution for DKA and duration of insulin infusion, varied depending on the endpoint were reported in the studies. Overall, balanced solutions were generally associated with faster correction of pH. The time to reach overall DKA endpoints was comparable in both groups. We concluded that crystalloid solutions may be used as an initial resuscitation fluid in the DKA population and may lead to earlier resolution of acidosis. More clinical trial data is required to reach statistical significance for the hypothesis. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Jahangir et al.) |
| Databáze: | MEDLINE |
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