Effectiveness of low-dose radiation therapy in COVID-19 patients globally: A systematic review.
| Autor: | Pandey SR; Medical Oncology, Nepal Cancer Hospital and Research Center, Lalitpur, Province 3, 44700, Nepal., Adhikari Yadav S; Patan Academy of Health Sciences School of Medicine, Kathmandu, 44600, Nepal., Gautam S; B.P. Koirala Institute of Health Sciences, Dharan, 44705, Nepal., Giri K; B.P. Koirala Cancer Hospital, Chitwan, 44204, Nepal., Devkota A; Patan Academy of Health Sciences, Kathmandu, 44600, Nepal., Shrestha S; Shahid Gangalal National Heart Center, Kathmandu, 44600, Nepal., Bhandari S; Shahid Gangalal National Heart Center, Kathmandu, 44600, Nepal., Baniya S; Metro City Hospital PVT Limited, Pokhara, 33700, Nepal., Adhikari B; Aamda Hospital Damak, Damak, 56604, Nepal., Adhikari B; Medical Oncology, Nepal Cancer Hospital and Research Center, Lalitpur, Province 3, 44700, Nepal., Neupane S; Patan Academy of Health Sciences School of Medicine, Kathmandu, 44600, Nepal., Bhandari J; All Nepal College of Medical Education, Kathmandu, 44600, Nepal. |
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| Jazyk: | angličtina |
| Zdroj: | F1000Research [F1000Res] 2022 Jan 19; Vol. 11, pp. 62. Date of Electronic Publication: 2022 Jan 19 (Print Publication: 2022). |
| DOI: | 10.12688/f1000research.74558.1 |
| Abstrakt: | Background: Novel Corona Virus Disease 2019 (COVID-19) can affect multiple organs, including the lungs, resulting in pneumonia. Apart from steroids, other anti-COVID drugs that have been studied appear to have little or no effect on COVID-19 pneumonia. There is a well-known history of inflammatory disease, including pneumonia, treated with low-dose radiation therapy (LDRT). It reduces the production of proinflammatory cytokines, Interleukin-1a (IL-1a), and leukocyte recruitment. Methods: A comprehensive literature search was conducted using PubMed, Scopus, Embase, CINAHL, and Google Scholar, with keywords such as "radiotherapy," "low-dose radiation therapy," "low-dose irradiation," "covid-19 pneumonia," "SARS-CoV-2 pneumonia," and "covid pneumonia." with additional filters for human studies and customized articles in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. We reviewed randomized controlled trials, quasi-experimental studies, cohort, case-control, and cross-sectional studies with a clearly defined intervention, including low-dose radiotherapy alone or in combination with any therapy to treat COVID-19 pneumonia from December 2019 to May 2021. Patients receiving standard or high-dose radiotherapy, including for other diseases, were excluded. Zotero software was used to collect and organize research from various databases, remove duplicates, extract relevant data, and record decisions. Participants' demographics and baseline status were obtained from the full-text articles along with the intervention's outcome/effect on patient status. Results: Four studies with 61 participants that met the inclusion criteria were included. One was a double-blind randomized controlled trial, one a non-randomized trial, while the other two were single-arm clinical trials. Low-dose radiation therapy did not show any significant improvement in COVID-19 patients. Conclusion: Only two studies included in this review demonstrated an improvement in inflammatory markers; however, patients were also given steroids or other drugs. Therefore, the confounding effects must be considered before drawing conclusions. This systematic review does not support mortality benefit, clinical course improvement, or imaging changes with LDRT. Competing Interests: No competing interests were disclosed. (Copyright: © 2022 Pandey SR et al.) |
| Databáze: | MEDLINE |
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