Extracellular Vesicles in Transplantation.
| Autor: | Sailliet N; Nantes Université, INSERM, Centeer for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, France., Ullah M; MSC-med, INSERM U7057, Universite de Paris, Paris, France., Dupuy A; Nantes Université, INSERM, Centeer for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, France., Silva AKA; MSC-med, INSERM U7057, Universite de Paris, Paris, France., Gazeau F; MSC-med, INSERM U7057, Universite de Paris, Paris, France., Le Mai H; Nantes Université, INSERM, Centeer for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, France., Brouard S; Nantes Université, INSERM, Centeer for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, France.; Labex IGO, Nantes, France. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in immunology [Front Immunol] 2022 Feb 03; Vol. 13, pp. 800018. Date of Electronic Publication: 2022 Feb 03 (Print Publication: 2022). |
| DOI: | 10.3389/fimmu.2022.800018 |
| Abstrakt: | Extracellular vesicles (EVs) have been extensively studied in the last two decades. It is now well documented that they can actively participate in the activation or regulation of immune system functions through different mechanisms, the most studied of which include protein-protein interactions and miRNA transfers. The functional diversity of EV-secreting cells makes EVs potential targets for immunotherapies through immune cell-derived EV functions. They are also a potential source of biomarkers of graft rejection through donor cells or graft environment-derived EV content modification. This review focuses on preclinical studies that describe the role of EVs from different cell types in immune suppression and graft tolerance and on the search for biomarkers of rejection. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Sailliet, Ullah, Dupuy, Silva, Gazeau, Le Mai and Brouard.) |
| Databáze: | MEDLINE |
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