Habenular Involvement in Response to Subcallosal Cingulate Deep Brain Stimulation for Depression.
| Autor: | Elias GJB; Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, ON, Canada., Germann J; Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, ON, Canada., Loh A; Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, ON, Canada., Boutet A; Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, ON, Canada.; Joint Department of Medical Imaging, University of Toronto, Toronto, ON, Canada., Pancholi A; Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, ON, Canada., Beyn ME; Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, ON, Canada., Bhat V; Centre for Mental Health and Krembil Research Centre, University Health Network, Toronto, ON, Canada., Woodside DB; Centre for Mental Health, University Health Network, Toronto, ON, Canada., Giacobbe P; Department of Psychiatry, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, ON, Canada., Kennedy SH; Centre for Mental Health, University Health Network, Toronto, ON, Canada.; Krembil Research Institute, University of Toronto, Toronto, ON, Canada., Lozano AM; Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, ON, Canada.; Krembil Research Institute, University of Toronto, Toronto, ON, Canada. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in psychiatry [Front Psychiatry] 2022 Feb 04; Vol. 13, pp. 810777. Date of Electronic Publication: 2022 Feb 04 (Print Publication: 2022). |
| DOI: | 10.3389/fpsyt.2022.810777 |
| Abstrakt: | The habenula (Hb) is a small, evolutionarily conserved epithalamic structure implicated in functions such as reward and mood regulation. Prior imaging work suggests that Hb's structural and functional properties may relate to treatment response in depression and other mood disorders. We used multimodal MRI techniques to investigate the potential involvement of Hb in response to subcallosal cingulate area deep brain stimulation (SCC-DBS) for treatment-resistant mood disorders. Using an automated segmentation technique, we compared Hb volume at baseline and at a subsequent post-operative timepoint (4.4 ± 3.0 years after surgery) in a cohort of 32 patients who received SCC-DBS. Clinical response to treatment (≥50% decrease in HAMD-17 from baseline to 12 months post-operation) was significantly associated with longitudinal Hb volume change: responders tended to have increased Hb volume over time, while non-responders showed decreased Hb volume ( t = 2.4, p = 0.021). We additionally used functional MRI (fMRI) in a subcohort of SCC-DBS patients ( n = 12) to investigate immediate within-patient changes in Hb functional connectivity associated with SCC-DBS stimulation. Active DBS was significantly associated with increased Hb connectivity to several prefrontal and corticolimbic regions (TFCE-adjusted p Competing Interests: AML is the co-founder of Functional Neuromodulation (a DBS-related company), is a consultant for Boston Scientific, Medtronic, and Abbott (companies that produce DBS hardware). PG and SK are consultants for Abbott. GE, AB, and AML have intellectual property in the field of DBS. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Elias, Germann, Loh, Boutet, Pancholi, Beyn, Bhat, Woodside, Giacobbe, Kennedy and Lozano.) |
| Databáze: | MEDLINE |
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