CdSe magic-sized quantum dots attenuate reactive oxygen species generated by neutrophils and macrophages with implications in experimental arthritis.

Autor: Saraiva AL; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil., Vieira TN; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil., Notário AFO; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil., Luiz JPM; Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil., Silva CR; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil., Goulart LR; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil., Dantas NO; Instituto de Física, Universidade Federal de Alagoas, Maceió, AL, Brazil., Silva ACA; Instituto de Física, Universidade Federal de Alagoas, Maceió, AL, Brazil., Espindola FS; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil. Electronic address: foued@ufu.br.
Jazyk: angličtina
Zdroj: Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2022 Jun; Vol. 42, pp. 102539. Date of Electronic Publication: 2022 Feb 18.
DOI: 10.1016/j.nano.2022.102539
Abstrakt: The biological applicability of nanomaterials has been limited due to cytotoxicity. Studies have described the effects of nanomaterials on different tissues and cell types, but their actions on immune cells are less elucidated. This study describes unprecedented in vitro and in vivo antioxidant activities of cadmium selenide magic-sized quantum dots (CdSe MSQDs) with implications on rheumatoid arthritis. While the generation of ROS induced by nanomaterials is linked to cytotoxicity, we found that CdSe MSQDs reduced ROS production by neutrophils and macrophages following opsonized-zymosan stimuli, and we did not find cytotoxic effects. Interestingly, inherent antioxidant properties of CdSe MSQDs were confirmed through DPPH, FRAP, and ORAC assays. Furthermore, CdSe MSQDs reduced ROS levels generated by infiltrating leukocytes into joints in experimental model of rheumatoid arthritis. Briefly, we describe a novel application of CdSe MSQDs in modulating the inflammatory response in experimental rheumatoid arthritis through an unexpected antioxidant activity.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: