Nail involvement in autosomal recessive congenital ichthyosis.

Autor: Zaouak A; Department of Dermatology, Research Unit Genodermatosis and Cancers LR12SP03, Habib Thameur Hospital, University of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia. Electronic address: anissa_zaouak@yahoo.fr., Chamli A; Department of Dermatology, Research Unit Genodermatosis and Cancers LR12SP03, Habib Thameur Hospital, University of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia., Ben Mansour N; Cardiovascular Epidemiology and Prevention Research Laboratory, University of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia., Jouini W; Department of Dermatology, Research Unit Genodermatosis and Cancers LR12SP03, Habib Thameur Hospital, University of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia., Fenniche S; Department of Dermatology, Research Unit Genodermatosis and Cancers LR12SP03, Habib Thameur Hospital, University of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia., Hammami H; Department of Dermatology, Research Unit Genodermatosis and Cancers LR12SP03, Habib Thameur Hospital, University of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Jazyk: angličtina
Zdroj: Clinics in dermatology [Clin Dermatol] 2022 Jul-Aug; Vol. 40 (4), pp. 388-394. Date of Electronic Publication: 2022 Feb 15.
DOI: 10.1016/j.clindermatol.2022.02.012
Abstrakt: Autosomal recessive congenital ichthyosis (ARCI) is a clinically and genetically heterogeneous category of nonsyndromic ichthyosis. Nail changes in ARCI are generally frequent but have been rarely reported and studied in the literature. This stimulated us to conduct a study to describe nail changes in ARCI using a combined literature review and prospective examination from March 2019 to August 2019 (6 months) in the Dermatology Department of Habib Thameur Hospital, Tunis, Tunisia. A total of 25 patients with ARCI had a clinical and dermatoscopic review. The mean age was 19.8 years (range, 1-43), with a female predominance (17 women [68%] and 8 men [32%]). Seventy-two percent had nail unit changes involving more than one nail, none had single nail disease, 64% had involvement of fingernails, and 68% had involvement of toenails, with cases including periungual hyperkeratosis (64%), xanthonychia (40%), pachyonychia (40%), macrolunula (36%), digital clubbing (32%), and onychomycosis (24%). Rarer findings included pseudoainhum, transverse leukonychia, longitudinal melanonychia, and subungual hemorrhages, each in one patient (4%). There was a statistically significant increased frequency of nail changes in adults over children (P = .001). Nail abnormalities statistically associated with ARCI were macrolunula, periungual hyperkeratosis, xanthonychia, and pachyonychia. A comprehensive review of the literature was performed, creating the first comprehensive review addressing nail disease in ARCI.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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