| Autor: |
Chou YH; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan.; Neuroscience Program of Academia Sinica, Academia Sinica, Taipei 11529, Taiwan.; Genome and Systems Biology Degree Program, Academia Sinica and National Taiwan University, Taipei 10617, Taiwan., Yang CJ; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan., Huang HW; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan., Liou NF; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan., Panganiban MR; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan., Luginbuhl D; Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, CA 94305, USA., Yin Y; Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK., Taisz I; Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK., Liang L; Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, CA 94305, USA., Jefferis GSXE; Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK.; Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK., Luo L; Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, CA 94305, USA. |
| Abstrakt: |
Variations in neuronal connectivity occur widely in nervous systems from invertebrates to mammals. Yet, it is unclear how neuronal variability originates, to what extent and at what time scales it exists, and what functional consequences it might carry. To assess inter- and intraindividual neuronal variability, it would be ideal to analyze the same identified neuron across different brain hemispheres and individuals. Here, using genetic labeling and electron microscopy connectomics, we show that an identified inhibitory olfactory local interneuron, TC-LN, exhibits extraordinary variability in its glomerular innervation patterns. Moreover, TC-LN's innervation of the VL2a glomerulus, which processes food signals and modulates mating behavior, is sexually dimorphic, is influenced by female's courtship experience, and correlates with food intake in mated females. Mating also affects output connectivity of TC-LN to specific local interneurons. We propose that mating-associated variability of TC-LNs regulates how food odor is interpreted by an inhibitory network to modulate feeding. |
