A series of case studies illustrating the role of flow cytometry in the diagnostic work-up of myelodysplastic syndromes.

Autor: Westers TM; Department of Hematology, Amsterdam University Medical Centers, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands., Saft L; Department of Pathology, Division of Hematopathology, Karolinska University Hospital and Institute, Stockholm, Sweden., van der Velden VHJ; Laboratory Medical Immunology, Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Te Marvelde JG; Laboratory Medical Immunology, Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Dunlop A; Department of Haemato-Oncology, Royal Marsden Hospital, London, UK.; Department of Haematology and SE-HMDS, King's College Hospital NHS Foundation Trust, London, UK., Ireland R; Department of Haematology and SE-HMDS, King's College Hospital NHS Foundation Trust, London, UK., Valent P; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Porwit A; Department of Clinical Sciences, Oncology and Pathology, Faculty of Medicine, Lund University, Lund, Sweden., Béné MC; Hematology Biology, Nantes University Hospital and CRCINA, Nantes, France., van de Loosdrecht AA; Department of Hematology, Amsterdam University Medical Centers, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands.
Jazyk: angličtina
Zdroj: Cytometry. Part B, Clinical cytometry [Cytometry B Clin Cytom] 2023 Jan; Vol. 104 (1), pp. 87-97. Date of Electronic Publication: 2022 Feb 18.
DOI: 10.1002/cyto.b.22061
Abstrakt: Current guidelines recommend flow cytometric analysis as part of the diagnostic assessment of patients with cytopenia suspected for myelodysplastic syndrome. Herein we describe the complete work-up of six cases using multimodal integrated diagnostics. Flow cytometry assessments are illustrated by plots from conventional and more recent analysis tools. The cases demonstrate the added value of flow cytometry in case of hypocellular, poor quality, or ambiguous bone marrow cytomorphology. Moreover, they demonstrate how immunophenotyping results support clinical decision-making in inconclusive and clinically 'difficult' cases.
(© 2022 The Authors. Cytometry Part B: Clinical Cytometry published by Wiley Periodicals LLC on behalf of International Clinical Cytometry Society.)
Databáze: MEDLINE
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