Leukocyte Telomere Length and Childhood Onset of Systemic Lupus Erythematosus in the Black Women's Experiences Living with Lupus Study.

Autor: Bridges J; Division of Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, USA.; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA., Chung KW; Department of Social, Behavioral, and Population Sciences, Tulane University, New Orleans, USA., Martz CD; Department of Human Development and Family Science, Auburn University, Auburn, USA., Smitherman EA; Division of Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, USA., Drenkard C; Division of Rheumatology, Emory University, Atlanta, USA., Wu C; School of Medicine, University of California San Francisco, San Francisco, USA., Lin J; School of Medicine, University of California San Francisco, San Francisco, USA., Lim SS; Division of Rheumatology, Emory University, Atlanta, USA., Chae DH; Department of Social, Behavioral, and Population Sciences, Tulane University, New Orleans, USA.
Jazyk: angličtina
Zdroj: ACR open rheumatology [ACR Open Rheumatol] 2022 May; Vol. 4 (5), pp. 426-431. Date of Electronic Publication: 2022 Feb 17.
DOI: 10.1002/acr2.11411
Abstrakt: Objective: The study objective was to compare leukocyte telomere length (LTL) among patients with systemic lupus erythematosus (SLE) diagnosed in childhood versus adulthood.
Methods: Data are from the Black Women's Experiences Living with Lupus (BeWELL) study. Multivariable linear regression analyses that examined childhood diagnosis of SLE (diagnosed before 18 years of age), age, and their interaction in relationship to LTL were conducted, adjusting for a range of demographic, socioeconomic, and health-related covariates.
Results: The total analytic sample size was 415. Forty participants (9.6%) were diagnosed in childhood. There was no main effect of childhood diagnosis on LTL (b = 0.007; 95% confidence interval [CI]: -0.089 to 0.103). However, the interaction between age and childhood diagnosis was significant (b = -0.008; 95% CI: -0.016 to -0.001), indicating a steeper inverse association between age and LTL among those diagnosed in childhood compared with those diagnosed in adulthood. This interaction remained statistically significant (P = 0.024) after controlling for disease duration measured dichotomously (less than 10 years vs. 10 years or more); it was marginally significant (P = 0.083) when controlling for disease duration measured continuously.
Conclusion: This cross-sectional analysis suggests that Black women with childhood-onset SLE may undergo accelerated LTL shortening compared with their adult-onset counterparts. This relationship persisted even after controlling for differences in SLE damage and disease duration. These findings inform research on immunosenescence mechanisms of SLE.
(© 2022 The Authors. ACR Open Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology.)
Databáze: MEDLINE
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