Urine and vaginal microbiota compositions of postmenopausal and premenopausal women differ regardless of recurrent urinary tract infection and renal transplant status.

Autor: Hugenholtz F; Center for Experimental and Molecular Medicine, Amsterdam University Medical Centers location AMC, Amsterdam, The Netherlands., van der Veer C; Public Health Laboratory, Public Health Service of Amsterdam (GGD), Amsterdam, The Netherlands.; Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi., Terpstra ML; Department of Internal Medicine, Division of Infectious Diseases, Amsterdam University Medical Centers, location AMC, Amsterdam, The Netherlands., Borgdorff H; Amsterdam Institute for Global Health and Development, Department of Global Health, Amsterdam University Medical Centers location AMC, Amsterdam, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands., van Houdt R; Department of Medical Microbiology and Infection Control, Amsterdam University Medical Centers location VUMc, Amsterdam, The Netherlands., Bruisten S; Public Health Laboratory, Public Health Service of Amsterdam (GGD), Amsterdam, The Netherlands., Geerlings SE; Department of Internal Medicine, Division of Infectious Diseases, Amsterdam University Medical Centers, location AMC, Amsterdam, The Netherlands., van de Wijgert JHHM; Amsterdam Institute for Global Health and Development, Department of Global Health, Amsterdam University Medical Centers location AMC, Amsterdam, The Netherlands. j.h.h.vandewijgert@umcutrecht.nl.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, Stratenum room 7.127, 3584 CG, Utrecht, The Netherlands. j.h.h.vandewijgert@umcutrecht.nl.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Feb 17; Vol. 12 (1), pp. 2698. Date of Electronic Publication: 2022 Feb 17.
DOI: 10.1038/s41598-022-06646-1
Abstrakt: Postmenopausal women and renal transplant recipients are at increased risk of recurrent urinary tract infections (RUTI). Urine and vaginal microbiota of premenopausal controls (N = 18) and RUTI cases (18), and of postmenopausal controls (30) and RUTI cases (20) with and without a renal transplant, were characterized using 16S rRNA sequencing. Participants did not have UTI symptoms at the time of sampling. Gram-negative uropathobionts (predominantly Escherichia/Shigella, Pseudomonas, Klebsiella, and Acinetobacter) had a much higher mean relative abundance in urine than vaginal samples, especially in premenopausal women. No statistically significant differences in mean relative abundances of bacterial groups were found within the premenopausal group or within the postmenopausal group by RUTI or renal transplant status without chronic antibiotic use. Comparing postmenopausal to premenopausal women, mean relative abundances of lactobacilli (especially L. crispatus) in urine and vaginal samples and of Gram-negative uropathobionts in urine were lower, and of BV-anaerobes and Gram-positive uropathobionts in urine and vaginal samples were higher. While RUTI in premenopausal women is predominantly caused by Escherichia, the causative organisms in postmenopausal women are likely more diverse. The relative importance of individual organisms is currently unknown. We recommend that future studies, including intervention studies, include longitudinal microbiota assessments.
(© 2022. The Author(s).)
Databáze: MEDLINE
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