Analysis of effects of acute hypovolemia on arterial stiffness in rabbits monitored with cardio-ankle vascular index.

Autor:	Nagasawa Y; Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Japan. Electronic address: yoshinobu.nagasawa@phar.toho-u.ac.jp., Shimoda A; Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Japan., Shiratori H; Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Japan., Morishita T; Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Japan., Sakuma K; Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Japan; Department of Pharmacy, Toho University Sakura Medical Center, Japan., Chiba T; Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Japan; Department of Pharmacy, Toho University Ohashi Medical Center, Japan., Cao X; Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Japan; Acupuncture and Tuina School/Third Teaching Hospital, Chengdu University of Traditional Chinese Medicine, China., Kawakami S; Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Japan., Aimoto M; Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Japan., Miyazaki C; Department of Neurosurgery, Tokyo Kamata Medical Center, Japan., Sato S; Department of Internal Medicine, Toho University Sakura Medical Center, Japan., Takahashi M; Department of Internal Medicine, Toho University Sakura Medical Center, Japan., Shimizu K; Department of Internal Medicine, Toho University Sakura Medical Center, Japan., Shirai K; Department of Vascular Function, Toho University Sakura Medical Center, Japan; Mihama Hospital, Japan., Takahara A; Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Japan.
Jazyk:	angličtina
Zdroj:	Journal of pharmacological sciences [J Pharmacol Sci] 2022 Mar; Vol. 148 (3), pp. 331-336. Date of Electronic Publication: 2022 Jan 24.
DOI:	10.1016/j.jphs.2022.01.008
Abstrakt:	Although elasticity of the conduit arteries is known to be contribute effective peripheral circulation via Windkessel effects, the relationship between changes in intra-aortic blood volume and conduit artery elasticity remains unknown. Here we assessed the effects of change in intra-aortic blood volume induced by blood removal and subsequent blood transfusion on arterial stiffness and the involvement of autonomic nervous activity using our established rabbit model in the presence or absence of the ganglion blocker hexamethonium (100 mg/kg). Blood removal at a rate of 1 mL/min gradually decreased the blood pressure and blood flow of the common carotid artery but increased a stiffness indicator the cardio-ankle vascular index, which was equally observed in the presence of hexamethonium. These results suggest that arterial stiffness acutely responds to changes in intra-aortic blood volume independent of autonomic nervous system modification. Competing Interests: Declaration of competing interest This study was funded by Fukuda Denshi Co., Ltd. (Copyright © 2022 The Authors. Production and hosting by Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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