ILC2s - development, divergence, dispersal.

Autor: Ricardo-Gonzalez RR; Department of Dermatology, University of California San Francisco, San Francisco, CA, USA; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA., Molofsky AB; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA; Diabetes Center, University of California San Francisco, San Francisco, CA, USA., Locksley RM; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA; Department of Medicine, University of California San Francisco, San Francisco, CA, USA; Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA. Electronic address: Richard.Locksley@ucsf.edu.
Jazyk: angličtina
Zdroj: Current opinion in immunology [Curr Opin Immunol] 2022 Apr; Vol. 75, pp. 102168. Date of Electronic Publication: 2022 Feb 14.
DOI: 10.1016/j.coi.2022.102168
Abstrakt: Over the last decade, we have come to appreciate group 2 innate lymphoid cells (ILC2s) as important players in host and tissue immunity. New studies of ILC2s and their precursors using novel reporter mice, advanced microscopy, and multi-omics approaches have expanded our knowledge on how these cells contribute to tissue physiology and function. This review highlights recent literature on this enigmatic cell, and we organize our discussion across three important paradigms in ILC2 biology: development, divergence, and dispersal. In addition, we frame our discussion in the context of other innate and adaptive immune cells to emphasize the relevance of expanding knowledge of ILC2s and tissue immunity.
(Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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