Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort.

Autor: Kilsdonk E; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Amsterdam UMC, Location AMC, Amsterdam, The Netherlands., van Dulmen-den Broeder E; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.; VU University Medical Center, Amsterdam, The Netherlands., van Leeuwen FE; Netherlands Cancer Institute, Amsterdam, The Netherlands., van den Heuvel-Eibrink MM; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Erasmus Medical Center/Sophia Children's Hospital, Rotterdam, The Netherlands., Loonen JJ; Radboud University Medical Center, Nijmegen, The Netherlands., van der Pal HJ; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.; UMC Amsterdam, Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands., Bresters D; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Willem Alexander Children's Hospital/Leiden University Medical Center, Leiden, The Netherlands., Versluys AB; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.; University Medical Center Utrecht, Utrecht, The Netherlands., Pieters R; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands., Hauptmann M; Netherlands Cancer Institute, Amsterdam, The Netherlands.; Brandenburg Medical School Theodor Fontane, Neuruppin, Germany., Jaspers MWM; Amsterdam UMC, Location AMC, Amsterdam, The Netherlands., Neggers SJC; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Erasmus Medical Center, Rotterdam, The Netherlands., Raphael MF; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.; UMC Amsterdam, Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands.; Stichting KinderOncologie Nederland (SKION)/Dutch Childhood Oncology Group (DCOG), The Hague, The Netherlands., Tissing WJE; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.; University of Groningen/University Medical Center Groningen, Groningen, The Netherlands., Kremer LCM; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.; UMC Amsterdam, Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands., Ronckers CM; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.; UMC Amsterdam, Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands.; Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.
Jazyk: angličtina
Zdroj: Cancer investigation [Cancer Invest] 2022 May; Vol. 40 (5), pp. 413-424. Date of Electronic Publication: 2022 Mar 07.
DOI: 10.1080/07357907.2022.2034841
Abstrakt: This multi-center cohort-study examined late mortality among 6,165 Dutch five-year childhood cancer survivors diagnosed 1963-2001. Clinical details and cause of death were based on medical records. Mortality was 12-fold that of the general population, with 51.3 additional deaths per 10,000 person-years (21.9 yrs median follow-up). Cumulative mortality 15 yrs post-diagnosis was 6.9%, predominantly from late recurrences; thereafter the absolute contribution of other health outcomes increased. Cumulative all-cause and recurrence-related mortality were highest for Central Nervous System and bone tumor survivors. All-cause, but not subsequent tumor and circulatory disease-related cumulative mortality, was highest for patients diagnosed 1963-1979 vs. later ( p -trend <0.001).
Databáze: MEDLINE
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