The Effect of Polymorphisms of Energy Metabolism Genes on Metabolic Disorders in Overweight Adolescents of Two Ethnicities.

Autor: Ievleva KD; Research Center for Family Health and Human Reproduction Problems, Irkutsk, Russia. asiy91@mail.ru., Bairova TA; Research Center for Family Health and Human Reproduction Problems, Irkutsk, Russia., Sheneman EA; Research Center for Family Health and Human Reproduction Problems, Irkutsk, Russia., Ayurova ZG; Research Center for Family Health and Human Reproduction Problems, Irkutsk, Russia., Balzhieva VV; Research Center for Family Health and Human Reproduction Problems, Irkutsk, Russia., Novikova EA; Research Center for Family Health and Human Reproduction Problems, Irkutsk, Russia., Bugun OV; Research Center for Family Health and Human Reproduction Problems, Irkutsk, Russia., Kolesnikov SI; Research Center for Family Health and Human Reproduction Problems, Irkutsk, Russia., Rychkova LV; Research Center for Family Health and Human Reproduction Problems, Irkutsk, Russia., Kolesnikova LI; Research Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2022 Feb; Vol. 172 (4), pp. 430-434. Date of Electronic Publication: 2022 Feb 17.
DOI: 10.1007/s10517-022-05408-3
Abstrakt: The aim of this cross-sectional observational study is to determine the contribution of polymorphisms of energy metabolism genes into metabolic disorders in Russian and Buryat adolescents with overweight and obesity. The study included 354 Russian and Buryat adolescents aged 13-18 years. Body mass index and serum levels of glucose, insulin, and leptin were measured and insulin resistance index HOMA-IR was calculated. Molecular genetic analysis for the presence of 9 loci of energy metabolism genes LEP, LEPR, POMC, FTO, and MC4R were analyzed. It was found that the risk of metabolic disorders is associated with the presence of polymorphic loci of leptin receptor gene LEPR and melanocortin receptor gene MC4R (LEPR rs1137100+LEPR rs1137101 and LEPR rs1137100+MC4R rs17782313) in Russian adolescents with overweight and obesity and polymorphisms of the gene FTO (FTO rs9939609+rs8050136) associated with fat mass and obesity in Buryat adolescents.
(© 2022. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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