Hepatocytic Apoptosis and Immune Dysfunction in Decompensation of Alcoholic Liver Cirrhosis with Different Grades of Acute-on-Chronic Liver Failure.

Autor: Rodina AS; Department of Propedeutics of Internal Diseases and Hygiene, Faculty of Medicine, Petrozavodsk State University, Petrozavodsk, Russia., Shubina ME; Department of Propedeutics of Internal Diseases and Hygiene, Faculty of Medicine, Petrozavodsk State University, Petrozavodsk, Russia., Kurbatova IV; Laboratory for Genetics, Institute of Biology of the Karelian Research Centre, Russian Academy of Sciences, Petrozavodsk, Russia., Topchieva LV; Laboratory for Genetics, Institute of Biology of the Karelian Research Centre, Russian Academy of Sciences, Petrozavodsk, Russia., Dudanova OP; Department of Propedeutics of Internal Diseases and Hygiene, Faculty of Medicine, Petrozavodsk State University, Petrozavodsk, Russia. odudanova@gmail.com.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2022 Feb; Vol. 172 (4), pp. 410-414. Date of Electronic Publication: 2022 Feb 17.
DOI: 10.1007/s10517-022-05404-7
Abstrakt: Acute-on-chronic liver failure (ACLF) of varying grades was assessed in 110 patients with alcoholic liver cirrhosis using the on-line CLIF-C ACLF Calculator ( www.efclif.com/scientific-activity/score-calculators/clif-c-aclf ); fragments of cytokeratin-18, TNFα, IL-1β, IL-4, IL-6, and IL-8 were also assayed. As ACLF progressed from grade 0 to grade 3, the levels of cytokeratin-18 fragments, IL-6, and IL-8 significantly increased, while IL-4 decreased. TNFα peaked in ACLF grade 1, but decreased in grades 2 and 3. IL-1β did not depend on the ACLF grade. Thus, hepatic damage and immune dysfunction are implicated in the progression of ACLF.
(© 2022. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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