Feasibility of Specimen Self-collection in Young Children Undergoing SARS-CoV-2 Surveillance for In-Person Learning.

Autor:	Altamirano J; Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford, California.; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California., Lopez M; Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford, California., Robinson IG; Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford, California., Chun LX; Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford, California., Tam GK; Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford, California., Shaikh NJ; Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford, California., Hoyte EG; Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California., Carrington YJ; Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford, California., Jani SG; Center for Policy, Outcomes, and Prevention, Department of Pediatrics, Stanford University School of Medicine, Stanford, California., Toomarian EY; Graduate School of Education, Stanford University, Stanford, California.; Synapse School, Menlo Park, California., Hsing JC; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California.; Center for Policy, Outcomes, and Prevention, Department of Pediatrics, Stanford University School of Medicine, Stanford, California., Ma J; Center for Policy, Outcomes, and Prevention, Department of Pediatrics, Stanford University School of Medicine, Stanford, California., Pulendran U; Center for Policy, Outcomes, and Prevention, Department of Pediatrics, Stanford University School of Medicine, Stanford, California., Govindarajan P; Department of Emergency Medicine, Stanford University School of Medicine, Stanford, California., Blomkalns AL; Department of Emergency Medicine, Stanford University School of Medicine, Stanford, California., Pinsky BA; Department of Pathology, Stanford University School of Medicine, Stanford, California., Wang CJ; Center for Policy, Outcomes, and Prevention, Department of Pediatrics, Stanford University School of Medicine, Stanford, California.; Department of Health Policy, Stanford University School of Medicine, Stanford, California., Maldonado Y; Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford, California.; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California.
Jazyk:	angličtina
Zdroj:	JAMA network open [JAMA Netw Open] 2022 Feb 01; Vol. 5 (2), pp. e2148988. Date of Electronic Publication: 2022 Feb 01.
DOI:	10.1001/jamanetworkopen.2021.48988
Abstrakt:	Importance: There is an urgent need to assess the feasibility of COVID-19 surveillance measures in educational settings. Objective: To assess whether young children can feasibly self-collect SARS-CoV-2 samples for surveillance testing over the course of an academic year. Design, Setting, and Participants: This prospective pilot cohort study was conducted from September 10, 2020, to June 10, 2021, at a K-8 school in San Mateo County, California. The research consisted of quantitative data collection efforts: (1) demographic data collected, (2) student sample self-collection error rates, and (3) student sample self-collection time durations. Students were enrolled in a hybrid learning model, a teaching model in which students were taught in person and online, with students having the option to attend virtually as needed. Data were collected under waiver of consent from students participating in weekly SARS-CoV-2 testing. Main Outcomes and Measures: Errors over time for self-collection of nasal swabs such as contaminated swabs and inadequate or shallow swabbing; time taken for sample collection. Results: Of 296 participants, 148 (50.0%) were boys and 148 (50.0%) were girls. A total of 87 participants (29.2%) identified as Asian; 2 (0.6%), Black or African American; 13 (4.4%), Hispanic/Latinx; 103 (34.6%), non-Hispanic White; 87 (29.2%), multiracial; and 6 (2.0%), other. The median school grade was fourth grade. From September 2020 to March 2021, a total of 4203 samples were obtained from 221 students on a weekly basis, while data on error rates were collected. Errors occurred in 2.7% (n = 107; 95% CI, 2.2%-3.2%) of student encounters, with the highest rate occurring on the first day of testing (20 [10.2%]). There was an overall decrease in error rates over time. From April to June 2021, a total of 2021 samples were obtained from 296 students on a weekly basis while data on encounter lengths were collected. Between April and June 2021, 193 encounters were timed. The mean duration of each encounter was 70 seconds (95% CI, 66.4-73.7 seconds). Conclusions and Relevance: Mastery of self-collected lower nasal swabs is possible for children 5 years and older. Testing duration can be condensed once students gain proficiency in testing procedures. Scalability for larger schools is possible if consideration is given to the resource-intensive nature of the testing and the setting's weather patterns.
Databáze:	MEDLINE
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