Omega-3 Fatty Acid Supplementation and Its Impact on Systemic Inflammation and Body Weight in Patients With Cancer Cachexia-A Systematic Review and Meta-Analysis.

Autor:	de Castro GS; Departamento de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.; Departamento de Cirurgia, Cancer Metabolism Research Group, LIM 26-HC, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Andrade MF; Departamento de Biologia Celular e do Desenvolvimento, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.; Departamento de Cirurgia, Cancer Metabolism Research Group, LIM 26-HC, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Pinto FCS; Departamento de Cirurgia, Cancer Metabolism Research Group, LIM 26-HC, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Faiad JZ; Departamento de Cirurgia, Cancer Metabolism Research Group, LIM 26-HC, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Seelaender M; Departamento de Cirurgia, Cancer Metabolism Research Group, LIM 26-HC, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in nutrition [Front Nutr] 2022 Jan 31; Vol. 8, pp. 797513. Date of Electronic Publication: 2022 Jan 31 (Print Publication: 2021).
DOI:	10.3389/fnut.2021.797513
Abstrakt:	Body weight loss and inflammation are major alterations related to cancer cachexia, an important wasting syndrome highly prevalent in many types of cancer. Nutritional components modulate inflammation in several chronic diseases. Omega-3 fatty acids (n-3) are well known for their anti-inflammatory properties. However, the effects of n-3 on cancer cachexia are still controversial. This systematic review and meta-analysis aims to evaluate the reported effects of n-3 supplementation on body weight and inflammatory markers in patients with cancer cachexia. Articles indexed in the major scientific platforms were retrieved in agreement with the Preferring Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) and 167 references were initially found. After removing duplicates and applying the inclusion and exclusion criteria, this systematic review included six studies. Using a random-effects model with 95% CI, three effect sizes were expressed as standard mean difference (SMD). No differences were found regarding the effect of n-3 on interleukin-6, C-reactive protein, and albumin levels. Body weight analysis included only two studies, devoid of robust conclusions. The low number of studies, low sample size, and great intra-variability precluded a stronger analysis. More studies evaluating n-3 supplementation in cancer cachexia are still needed. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer AL declared a shared affiliation, though no other collaboration, with the authors GC, MA, FP, JF, and MS to the handling Editor. (Copyright © 2022 de Castro, Andrade, Pinto, Faiad and Seelaender.)
Databáze:	MEDLINE
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