Ineligibility for and Refusal to Participate in Randomized Controlled Trials That Have Studied Impact on Suicide-Related Outcomes in the United States: A Meta-Analysis.
| Autor: | Susukida R; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.; Dr Susukida and Dr Amin-Esmaeili contributed equally as co-first authors., Amin-Esmaeili M; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.; Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran.; Dr Susukida and Dr Amin-Esmaeili contributed equally as co-first authors., Ryan TC; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.; Forefront Suicide Prevention, Seattle, Washington., Kharrazi H; Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.; Division of Health Sciences Informatics, Johns Hopkins School of Medicine, Baltimore, Maryland., Wilson RF; Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Musci RJ; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Zhang A; Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Wissow L; Division of Child and Adolescent Psychiatry, University of Washington, Seattle, Washington.; Department of Health, Behavior, and Society, Johns Hopkins School of Public Health, Baltimore, Maryland., Robinson KA; JHU Evidence-based Practice Center, Johns Hopkins University, Baltimore, Maryland., Wilcox HC; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.; Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Johns Hopkins University School of Education, Baltimore, Maryland.; Corresponding author: Holly C. Wilcox, PhD, Johns Hopkins Bloomberg School of Public Health, 624 N. Broadway Room 801, Baltimore, MD 21205 (hwilcox@jhsph.edu). |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of clinical psychiatry [J Clin Psychiatry] 2022 Feb 15; Vol. 83 (2). Date of Electronic Publication: 2022 Feb 15. |
| DOI: | 10.4088/JCP.20r13798 |
| Abstrakt: | Objective: Ineligibility for and refusal to participate in randomized controlled trials (RCTs) can potentially lead to unrepresentative study samples and limited generalizability of findings. We examined the rates of exclusion and refusal in RCTs that have studied impact on suicide-related outcomes in the US. Data Sources: PubMed, the Cochrane Library, the Campbell Collaboration Library of Systematic Reviews, CINAHL, PsycINFO, and Education Resources Information Center were searched from January 1990 to May 2020 using the terms ( suicide prevention ) AND ( clinical trial ). Study Selection: Of 8,403 studies retrieved, 36 RCTs assessing effectiveness on suicide-related outcomes in youth (≤ 25 years old) conducted in the US were included. Data Extraction: Study-level data were extracted by 2 independent investigators for a random-effects meta-analysis and meta-regression. Results: The study participants (N = 13,264) had a mean (SD) age of 14.87 (1.58) years and were 50% male, 23% African American, and 24% Hispanic. The exclusion rate was 36.4%, while the refusal rate was 25.5%. The exclusion rate was significantly higher in the studies excluding individuals not exceeding specified cutoff points of suicide screening tools (51.2%; adjusted linear coefficient [β] = 1.30, standard error [SE] = 0.15; P = .041) and individuals not meeting the age or school grade criterion (45.9%; β = 1.37, SE = 0.13; P = .005). Conclusions: The rates of exclusion and refusal in youth prevention interventions studying impact on suicide-related outcomes were not as high compared to the rates found in other mental and behavioral interventions. While there was strong racial/ethnic group representation in RCTs examining youth suicide-related outcomes, suicide severity and age limited eligibility. (© Copyright 2022 Physicians Postgraduate Press, Inc.) |
| Databáze: | MEDLINE |
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