Serum kisspeptin, leptin, neuropeptide Y, and neurokinin B levels in adolescents with polycystic ovary syndrome.

Autor:	Guzelkas I; Department of Pediatrics, Ataturk University Faculty of Medicine, Erzurum, Turkey., Orbak Z; Department of Pediatric Endocrinology, Ataturk University Faculty of Medicine, Erzurum, Turkey., Doneray H; Department of Pediatric Endocrinology, Ataturk University Faculty of Medicine, Erzurum, Turkey., Ozturk N; Department of Biochemistry, Ataturk University Faculty of Medicine, Erzurum, Turkey., Sagsoz N; Department of Obstetrics and Gynecology, Kırıkkale University Faculty of Medicine, Kırıkkale, Turkey.
Jazyk:	angličtina
Zdroj:	Journal of pediatric endocrinology & metabolism : JPEM [J Pediatr Endocrinol Metab] 2022 Feb 16; Vol. 35 (4), pp. 481-487. Date of Electronic Publication: 2022 Feb 16 (Print Publication: 2022).
DOI:	10.1515/jpem-2021-0487
Abstrakt:	Objectives: Polycystic ovary syndrome (PCOS) is characterized by ovarian dysfunction, clinical and/or biochemical hyperandrogenism, and polycystic ovaries. Its pathogenesis is still unclear. This study aimed to investigate the relationship between kisspeptin, leptin, neuropeptide Y (NPY), and neurokinin B (NKB) levels for evaluating the pathogenesis of PCOS. Methods: Levels of these parameters were analyzed in 20 patients with PCOS, and 16 healthy adolescents. Results: Serum NPY levels were significantly higher in the obese and non-obese PCOS group (p<0.01). There was a negative correlation between the kisspeptin and the NKB levels (p<0.01) in the PCOS group but not in the control group. This negative correlation was also found in both PCOS groups (p<0.01). In the obese PCOS group, serum kisspeptin levels were significantly lower than the control and non-obese PCOS groups (p<0.05) although serum leptin and NPY levels were significantly higher in the obese PCOS group (p<0.01). Conclusions: The high NPY levels in both obese and non-obese patients with PCOS indicate that NPY plays a role in the pathogenesis independently from obesity. Significantly high leptin and low kisspeptin levels in the obese PCOS group suggested that they may be associated with obesity rather than PCOS. (© 2022 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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