The fornix supports episodic memory during childhood.

Autor:	Hoffman LJ; Department of Psychology, Temple University, 1701 North 13th St., Philadelphia, PA 19122, USA., Ngo CT; Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany., Canada KL; Institute of Gerontology, Wayne State University, 87 East Ferry St., Detroit, MI 48202, USA., Pasternak O; Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA 02115, USA.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston MA 02115, USA., Zhang F; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston MA 02115, USA., Riggins T; Department of Psychology, University of Maryland, 4094 Campus Dr., College Park, MD, 20742, USA., Olson IR; Department of Psychology, Temple University, 1701 North 13th St., Philadelphia, PA 19122, USA.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2022 Nov 21; Vol. 32 (23), pp. 5388-5403.
DOI:	10.1093/cercor/bhac022
Abstrakt:	Episodic memory relies on the coordination of widespread brain regions that reconstruct spatiotemporal details of an episode. These topologically dispersed brain regions can rapidly communicate through structural pathways. Research in animal and human lesion studies implicate the fornix-the major output pathway of the hippocampus-in supporting various aspects of episodic memory. Because episodic memory undergoes marked changes in early childhood, we tested the link between the fornix and episodic memory in an age window of robust memory development (ages 4-8 years). Children were tested on the stories subtest from the Children's Memory Scale, a temporal order memory task, and a source memory task. Fornix streamlines were reconstructed using probabilistic tractography to estimate fornix microstructure. In addition, we measured fornix macrostructure and computed free water. To assess selectivity of our findings, we also reconstructed the uncinate fasciculus. Findings show that children's memory increases from ages 4 to 8 and that fornix micro- and macrostructure increases between ages 4 and 8. Children's memory performance across nearly every memory task correlated with individual differences in fornix, but not uncinate fasciculus, white matter. These findings suggest that the fornix plays an important role in supporting the development of episodic memory, and potentially semantic memory, in early childhood. (Published by Oxford University Press 2022.)
Databáze:	MEDLINE
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