Pain Burden in the CASiRe International Cohort of Sickle Cell Patients: United States and Ghana.

Autor:	Zempsky WT; Department of Pediatrics, University of Connecticut School of Medicine, Connecticut Children's Medical Center, Hartford, Connecticut, USA., Yanaros M; University of Connecticut School of Medicine, Farmington, Connecticut, USA., Sayeem M; University of Connecticut School of Medicine, Farmington, Connecticut, USA., Boruchov D; Department of Pediatrics, University of Connecticut School of Medicine, Connecticut Children's Medical Center, Hartford, Connecticut, USA., Piccone CM; Pediatric Hematology/Oncology, Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA., Manwani D; Department of Pediatrics, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, New York, USA., Strunk C; ProMedica Russell J. Ebeid Children's Hospital, Toledo, Ohio, USA., Tartaglione I; Department of Woman, Child and Generalized and Special Surgery, University of Campania 'L. Vanvitelli,' Naples, Italy., Colombatti R; Department of Women's and Children's Health, University of Padua, Padua, Italy., Akatue S; Division of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA., Oteng B; Division of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA., Owda A; Division of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA., Bamfo R; Division of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA., Wilson S; Division of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA., Rivers A; UCSF Benioff Children's Hospital Oakland, Oakland, California, USA., Farooq F; Division of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA., Urbonya R; Division of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA., Boatemaa GD; Department of Physiology, University of Ghana Medical School, Accra, Ghana., Rao S; Department of Child Health, University of Ghana Medical School, Accra, Ghana., Inusa B; Department of Pediatrics, Paediatric Haematology, Guys and St Thomas Hospital, London, UK., Antwi-Boasiako C; Department of Physiology, University of Ghana Medical School, Accra, Ghana.; Ghana Institute of Clinical Genetics, Korle Bu Teaching Hospital, Accra, Ghana., Segbefia C; Department of Child Health, University of Ghana Medical School, Accra, Ghana., Sey F; Ghana Institute of Clinical Genetics, Korle Bu Teaching Hospital, Accra, Ghana., Andemariam B; New England Sickle Cell Institute, University of Connecticut Health Center, Farmington, Connecticut, USA., Asare EV; Ghana Institute of Clinical Genetics, Korle Bu Teaching Hospital, Accra, Ghana., Campbell AD; Division of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA.; Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC, USA.
Jazyk:	angličtina
Zdroj:	Pain medicine (Malden, Mass.) [Pain Med] 2022 Aug 01; Vol. 23 (8), pp. 1379-1386.
DOI:	10.1093/pm/pnac023
Abstrakt:	Objectives: Sickle Cell Disease (SCD) is a genetic blood disorder affecting over 1 million people globally. The aim of this analysis is to explore the pain burden of patients with SCD in two countries: the United States and Ghana. Methods: The Consortium for the Advancement of Sickle Cell Research (CASiRe) was created to better understand the clinical severity of patients with SCD worldwide. Data regarding gender, SCD genotype, prior medical diagnoses, and validated pain burden measures were analyzed from the CASiRe database. The Sickle Cell Pain Burden Interview (SCPBI) was used to assess pain burden, the impact of pain on physical, emotional, and social function. Results: Most subjects identified as Black/African American (n = 298, 97.0%). Patient ages ranged from 6 to 73 years. 35.9% resided in the United States, 64.1% resided in Ghana, 40.9% were men, and 58.7% were women. The mean SCPBI score for US SCD patients was 6.53(±5.89) vs 4.04(±5.10) for Ghanaian patients, P <0.001. Pain burden was higher in US men vs Ghanaian men (6.74(±5.68) vs 3.54(±4.46), P = .003) and in US women vs Ghanaian women (6.37 ± 6.06 vs 4.44(±5.54), P = .032). Pain burden was higher in US patients than Ghanaian patients for both the Hb SC/SBeta+ genotype (5.40(±5.29) vs 2.82(±4.86), P = .054) and Hb SS/SBeta0 genotype (6.79(±6.01) vs 4.49(±5.13), P = .003). Pain burden was significantly higher in SCD patients with comorbid conditions independent of geographic origin including stroke, cholecystectomy, gallstones, depression, and headache. Discussion: US patients with SCD have a higher pain burden than Ghanaian patients. Further studies should investigate underlying contributors to pain burden in these populations and further explore the etiology of geographic differences in pain. (© The Author(s) 2022. Published by Oxford University Press on behalf of the American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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