Single fiber reflectance spectroscopy for pancreatic cancer detection during endoscopic ultrasound guided fine needle biopsy: a prospective cohort study.

Autor:	van Manen L; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands., Schmidt I; Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Inderson A; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Houvast RD; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands., Boonstra JJ; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Dijkstra J; Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands., van Hooft JE; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Nagengast WB; Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Robinson DJ; Department of Otorhinolaryngology and Head and Neck Surgery, Center for Optical Diagnostics and Therapy, Erasmus Medical Center, Rotterdam, The Netherlands., Vahrmeijer AL; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands., Mieog JSD; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Jazyk:	angličtina
Zdroj:	International journal of medical sciences [Int J Med Sci] 2022 Jan 01; Vol. 19 (2), pp. 205-212. Date of Electronic Publication: 2022 Jan 01 (Print Publication: 2022).
DOI:	10.7150/ijms.65364
Abstrakt:	This study aimed to determine the ability of single fiber reflectance (SFR) spectroscopy incorporated in endoscopic ultrasound fine needle biopsy (EUS-FNB) procedures in the pancreas to distinguish benign and malignant pancreatic tissue in patient with pancreatic masses suspected for malignancy. Methods: This study was designed as a prospective observational single center study and included consecutive adult patients, who were scheduled for EUS-FNB of a solid pancreatic mass suspected for pancreatic ductal adenocarcinoma (PDAC). In total, seven optical parameters, derived from the absorption acquired spectra, were analyzed: blood volume fraction (BVF), microvascular saturation, average vessel diameter, bilirubin concentration (BIL), Mie amplitude, Mie slope and Rayleigh amplitude. Results: Forty-five patients with a suspicious pancreatic lesion undergoing EUS-FNB were included, of which most of the patients (N=34) were ultimately diagnosed with PDAC. Finally, 27 out of 45 (60.0%) patients were used for the final analysis of the optical parameters. The median (IQR) BVF differed significantly in benign compared to malignant tissue (0.86 [0.30-2.03] and 4.49 [1.28-15.47]; p =0.046). Combining BVF and BIL to a new parameter ( θ ) improved the discrimination between PDAC and benign pancreatic tissue ( p =0.026). The area under the curve of θ was 0.84, resulting in a 92.8%, 75.0%, 97.5%, 50.0% and 91.3% sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy for detection of PDAC. Conclusion: Differentiation between PDAC and benign pancreatic tissue using SFR spectroscopy during EUS-FNB procedures is promising. Future work should focus on comparing the diagnostic performance combining SFR spectroscopy with EUS-FNB and EUS-FNB alone. Competing Interests: Competing Interests: The authors have declared that no competing interest exists. (© The author(s).)
Databáze:	MEDLINE
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