Extracorporeal photopheresis in chronic graft-versus-host disease: clinical description and economic study.
| Autor: | Vargas DF; Hospital Moinhos de Vento, Porto Alegre, RS, Brazil., Pereira MP; Hospital Moinhos de Vento, Porto Alegre, RS, Brazil., Silva TS; Hospital Moinhos de Vento, Porto Alegre, RS, Brazil. Electronic address: dora.varga@hmv.org.br., de David CN; Hospital Moinhos de Vento, Porto Alegre, RS, Brazil., Paz AA; Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil., Astigarraga CC; Hospital Moinhos de Vento, Porto Alegre, RS, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | Hematology, transfusion and cell therapy [Hematol Transfus Cell Ther] 2023 Apr-Jun; Vol. 45 (2), pp. 182-187. Date of Electronic Publication: 2021 Dec 09. |
| DOI: | 10.1016/j.htct.2021.08.014 |
| Abstrakt: | Introduction: Although extracorporeal photopheresis (ECP) is a promising second-line therapy in the treatment of chronic graft-versus-host disease (cGVHD), its use is limited by its high cost. This study aims to describe the clinical evolution of patients who underwent ECP therapy for cGVHD and to perform an economic analysis of the therapy METHODS: This was a case series between 2016 and 2020 describing the clinical response to ECP and a micro-cost analysis of the therapy using time-driven activity-based costing. Results: Six patients underwent ECP for corticosteroid-dependent cGVHD The cost per ECP session is 14,960.90 Brazilian reais (BRL), which primarily consists of the ECP kit with an activator (82.78%), followed by the hospital's physical structure (14.66%), human resources (2.48%) and exams/inputs (0.08%). The number of sessions performed ranged from 2 to 42. The total cost of the therapy per patient ranged from BRL 30,000 to 500,000. Conclusion: The response of the patient with cGVHD to treatment with ECP was variable. These micro-costing results can be used to develop remuneration and cost control strategies in hematopoietic stem cell transplantation programs, as well as in further economic studies. Competing Interests: Conflicts of interest None. (Copyright © 2021. Published by Elsevier España, S.L.U.) |
| Databáze: | MEDLINE |
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