| Autor: |
Elnagar GM; Biochemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt., Elseweidy MM; Biochemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt., Mahmoud YK; Biochemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt., Elkomy NMIM; Pharmacology and Toxicology Department, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt., Althafar ZM; Department of Medical Laboratories Sciences, College of Applied Medical Sciences in Al-Quwayiyah, Shaqra University, Riyadh 11564, Saudi Arabia., Alnomasy SF; Department of Medical Laboratories Sciences, College of Applied Medical Sciences in Al-Quwayiyah, Shaqra University, Riyadh 11564, Saudi Arabia., Al-Gabri NA; Department of Pathology, Faculty of Veterinary Medicine, Thamar University, Dhamar 124401, Yemen.; Laboratory of Pathology, Salam Veterinary Group, Buraydah 51911, Saudi Arabia., Shawky M; Department of Biochemistry, Faculty of Pharmacy, Horus University, New Damietta 34711, Egypt. |
| Abstrakt: |
Tramadol represents a synthetic opioid analgesic especially for mild to severe pain. Its dose must be commonly monitored according to pain status and to alleviate the appearance of any adverse effects such as renal cellular damage during its excretion. Present work aimed mainly to study the effects of tramadol intake on renal tissues and 10-dehydrogingerdione (10-DHGD) potential as a protective agent. Tramadol administration induced an increase in serum levels of urea, creatinine, uric acid, the renal immune expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and caspase-3 which turned out to be decreased by 10-DHGD intake. Our results also recorded a significant increase in renal malondialdehyde (MDA), toll-like receptor 4 (TLR4), and extracellular signal-regulated protein kinase-1 (ERK1) along with glutathione (GSH), superoxide dismutase (SOD), and heme oxygenase-1 (HO-1) decrease due to tramadol intake, which were counteracted by 10-DHGD administration as illustrated and supported by the histopathological findings. Our conclusion refers to renoprotective potential of 10-DHGD against tramadol adverse effects. |
