The Induced Pluripotent Stem Cells in Articular Cartilage Regeneration and Disease Modelling: Are We Ready for Their Clinical Use?

Autor: Lach MS; Radiobiology Laboratory, Greater Poland Cancer Centre, 61-866 Poznan, Poland.; Department of Orthopedics and Traumatology, Poznan University of Medical Sciences, 61-545 Poznan, Poland.; Department of Electroradiology, Poznan University of Medical Sciences, 61-866 Poznan, Poland., Rosochowicz MA; Radiobiology Laboratory, Greater Poland Cancer Centre, 61-866 Poznan, Poland.; Department of Orthopedics and Traumatology, Poznan University of Medical Sciences, 61-545 Poznan, Poland., Richter M; Department of Orthopedics and Traumatology, Poznan University of Medical Sciences, 61-545 Poznan, Poland., Jagiełło I; Greater Poland Cancer Centre, Department of Tumour Pathology, 61-866 Poznan, Poland., Suchorska WM; Radiobiology Laboratory, Greater Poland Cancer Centre, 61-866 Poznan, Poland.; Department of Electroradiology, Poznan University of Medical Sciences, 61-866 Poznan, Poland., Trzeciak T; Department of Orthopedics and Traumatology, Poznan University of Medical Sciences, 61-545 Poznan, Poland.
Jazyk: angličtina
Zdroj: Cells [Cells] 2022 Feb 03; Vol. 11 (3). Date of Electronic Publication: 2022 Feb 03.
DOI: 10.3390/cells11030529
Abstrakt: The development of induced pluripotent stem cells has brought unlimited possibilities to the field of regenerative medicine. This could be ideal for treating osteoarthritis and other skeletal diseases, because the current procedures tend to be short-term solutions. The usage of induced pluripotent stem cells in the cell-based regeneration of cartilage damages could replace or improve on the current techniques. The patient's specific non-invasive collection of tissue for reprogramming purposes could also create a platform for drug screening and disease modelling for an overview of distinct skeletal abnormalities. In this review, we seek to summarise the latest achievements in the chondrogenic differentiation of pluripotent stem cells for regenerative purposes and disease modelling.
Databáze: MEDLINE
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