An Insight on the Maternal-Fetal Outcomes of Critically Ill Pregnant Women During the Second Wave of COVID-19.

Autor:	Faraz S; Obstetrics and Gynecology, Dubai Medical College, Dubai, ARE.; Obstetrics and Gynecology, Latifa Women and Children Hospital, Dubai, ARE., Aftab N; Obstetrics and Gynecology, Dubai Medical College, Dubai, ARE.; Obstetrics and Gynecology, Latifa Women and Children Hospital, Dubai, ARE., Ammar A; Obstetrics and Gynecology, Dubai Medical College, Dubai, ARE.; Obstetrics and Gynecology, Latifa Women and Children Hospital, Dubai, ARE., Al Mulai I; Obstetrics and Gynecology, Dubai Medical College, Dubai, ARE.; Obstetrics and Gynecology, Latifa Women and Children Hospital, Dubai, ARE., Paulose L; Obstetrics and Gynecology, Dubai Medical College, Dubai, ARE.; Obstetrics and Gynecology, Latifa Women and Children Hospital, Dubai, ARE., Fernandes S; Obstetrics and Gynecology, Dubai Medical College, Dubai, ARE.; Obstetrics and Gynecology, Latifa Women and Children Hospital, Dubai, ARE.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2022 Jan 06; Vol. 14 (1), pp. e20998. Date of Electronic Publication: 2022 Jan 06 (Print Publication: 2022).
DOI:	10.7759/cureus.20998
Abstrakt:	Background:  Coronavirus disease 2019 (COVID-19) and other respiratory infections have been attributed to causing severe disease and pneumonia in pregnant women because of physiological stress and alterations in the immune system during pregnancy. Pregnant women are prone to develop serious outcomes for both mother and child when infected by previous coronaviruses, but there is a paucity of data regarding clinical characteristics and maternal-fetal outcomes in COVID-19. Moreover, various laboratory and radiological parameters are scarcely studied in pregnant women in the third trimester who develop severe COVID-19. Therefore, we conducted this study to assess and compare the maternal-fetal outcomes of critically ill pregnant women with COVID-19 pneumonia who required admission to the intensive care unit (ICU). Materials and Methods:  We conducted this retrospective observational study at a tertiary care hospital affiliated with an academic center in the United Arab Emirates. A total of 123 patients in their third trimester were included in the study from December 1, 2020, to March 31, 2021, comprising 30 cases of severe or critical COVID-19 and 93 mild to moderate COVID-19 patients. We collected and analyzed maternal demographic data and radiological and biochemical profiles. We also compared maternal-fetal outcomes. Results:  Thirty patients (24.3%) were admitted to the ICU, and eight required invasive ventilation. Severe COVID-19 pneumonia was significantly associated with higher mortality (20% vs. 0%; p < 0.001), postpartum complications (50% vs. 9.67%; p < 0.001), and increased overall hospital stay than mild to moderate COVID-19 (p < 0.001). In addition, the primary indication for intervention in severe cases was worsening of COVID-19 pneumonia, and pregnant patients had significantly greater chances of undergoing delivery by Cesarean section (80% vs. 40.8%; p = 0.01). Neonates born to severe COVID-19 patients had significantly higher chances of being born preterm (76.6% vs. 35.7%; p < 0.001) and had low birth weight (46.6% vs. 13.9%; p-value = 0.002). There were four stillbirth cases, two vertical transmission cases, and no neonatal deaths. Conclusions:  This study assessed and compared maternal-fetal outcomes of critically ill pregnant women with COVID-19 pneumonia who required admission to the ICU because of the paucity of data in this patient demographic. Pregnant women with severe COVID-19 have high mortality, peripartum complications, increased hospital stay, and are more likely to undergo Cesarean section delivery because of COVID-19 progression than pregnant patients with less severe forms of COVID-19. The newborns born to such mothers may be premature and have low birth weights but have similar mortality to those born to mothers with mild to moderate COVID-19. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Faraz et al.)
Databáze:	MEDLINE
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