Three-dimensional analysis of blood platelet spreading using digital holographic microscopy: a statistical study of the differential effect of coatings in healthy volunteers and dialyzed patients.

Autor:	Dohet-Eraly J; Laboratory of Experimental Medicine (ULB222), Faculty of Medicine, Université libre de Bruxelles, Centre hospitalier universitaire de Charleroi, 706 Rue de Gozée, 6110 Montigny-le-Tilleul, Belgium.; Microgravity Research Centre, Université libre de Bruxelles, 50 Avenue Franklin Roosevelt, 1050 Bruxelles, Belgium.; These authors contributed equally.; Jerome.Dohet-Eraly@ulb.ac.be., Boudjeltia KZ; Laboratory of Experimental Medicine (ULB222), Faculty of Medicine, Université libre de Bruxelles, Centre hospitalier universitaire de Charleroi, 706 Rue de Gozée, 6110 Montigny-le-Tilleul, Belgium.; These authors contributed equally.; Karim.Zouaoui.Boudjeltia@ulb.be., Rousseau A; Laboratory of Experimental Medicine (ULB222), Faculty of Medicine, Université libre de Bruxelles, Centre hospitalier universitaire de Charleroi, 706 Rue de Gozée, 6110 Montigny-le-Tilleul, Belgium., Queeckers P; Microgravity Research Centre, Université libre de Bruxelles, 50 Avenue Franklin Roosevelt, 1050 Bruxelles, Belgium., Lelubre C; Laboratory of Experimental Medicine (ULB222), Faculty of Medicine, Université libre de Bruxelles, Centre hospitalier universitaire de Charleroi, 706 Rue de Gozée, 6110 Montigny-le-Tilleul, Belgium.; Department of Internal Medicine, Centre hospitalier universitaire de Charleroi - Hôpital civil Marie Curie, 140 Chaussée de Bruxelles, 6042 Charleroi, Belgium., Desmet JM; Department of Nephrology, Centre hospitalier universitaire de Charleroi - Hôpital Vésale, 706 Rue de Gozée, 6110 Montigny-le-Tilleul, Belgium., Chopard B; Computer Science Department, University of Geneva, 7 Route de Drize, 1227 Carouge, Switzerland., Yourassowsky C; Microgravity Research Centre, Université libre de Bruxelles, 50 Avenue Franklin Roosevelt, 1050 Bruxelles, Belgium., Dubois F; Microgravity Research Centre, Université libre de Bruxelles, 50 Avenue Franklin Roosevelt, 1050 Bruxelles, Belgium.
Jazyk:	angličtina
Zdroj:	Biomedical optics express [Biomed Opt Express] 2021 Dec 24; Vol. 13 (1), pp. 502-513. Date of Electronic Publication: 2021 Dec 24 (Print Publication: 2022).
DOI:	10.1364/BOE.448817
Abstrakt:	In cardiovascular disorders, the study of thrombocytes, commonly known as platelets, is highly important since they are involved in blood clotting, essential in hemostasis, and they can in pathological situations affect the blood circulation. In this paper, single deposited platelets are measured using interferometric digital holographic microscopy. We have shown that the average optical height of platelets is significantly lower in healthy volunteers than in dialyzed patients, meaning a better spreading. It demonstrates the great interest for assessing this parameter in any patients, and therefore the high potential of analyzing single spread platelets using digital holographic microscopy in fundamental research as well as a diagnostic tool in routine laboratories, for usual blood tests. Competing Interests: The authors declare no conflict of interest. (© 2021 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.)
Databáze:	MEDLINE
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