Changes in Sensorimotor Connectivity to dI3 Interneurons in Relation to the Postnatal Maturation of Grasping.

Autor:	Laliberte AM; Brain and Mind Research Institute, Department of Biology, University of Ottawa, Ottawa, ON, Canada., Farah C; Brain and Mind Research Institute, Department of Biology, University of Ottawa, Ottawa, ON, Canada., Steiner KR; Brain and Mind Research Institute, Department of Biology, University of Ottawa, Ottawa, ON, Canada., Tariq O; School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada., Bui TV; Brain and Mind Research Institute, Department of Biology, University of Ottawa, Ottawa, ON, Canada.
Jazyk:	angličtina
Zdroj:	Frontiers in neural circuits [Front Neural Circuits] 2022 Jan 27; Vol. 15, pp. 768235. Date of Electronic Publication: 2022 Jan 27 (Print Publication: 2021).
DOI:	10.3389/fncir.2021.768235
Abstrakt:	Primitive reflexes are evident shortly after birth. Many of these reflexes disappear during postnatal development as part of the maturation of motor control. This study investigates the changes of connectivity related to sensory integration by spinal dI3 interneurons during the time in which the palmar grasp reflex gradually disappears in postnatal mice pups. Our results reveal an increase in GAD65/67-labeled terminals to perisomatic Vglut1-labeled sensory inputs contacting cervical and lumbar dI3 interneurons between postnatal day 3 and day 25. In contrast, there were no changes in the number of perisomatic Vglut1-labeled sensory inputs to lumbar and cervical dI3 interneurons other than a decrease between postnatal day 15 and day 25. Changes in postsynaptic GAD65/67-labeled inputs to dI3 interneurons were inconsistent with a role in the sustained loss of the grasp reflex. These results suggest a possible link between the maturation of hand grasp during postnatal development and increased presynaptic inhibition of sensory inputs to dI3 interneurons. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Laliberte, Farah, Steiner, Tariq and Bui.)
Databáze:	MEDLINE
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