Real-world practice of acute leukemia intrathecal chemotherapy administration: A Mexican nationwide survey.

Autor:	Colunga-Pedraza JE; Hospital Universitario 'Dr. José Eleuterio Gonzalez', Nuevo León, México., Colunga-Pedraza PR; Hospital Universitario 'Dr. José Eleuterio Gonzalez', Nuevo León, México., Benavides-López HV; Hospital Universitario 'Dr. José Eleuterio Gonzalez', Nuevo León, México., Mares-Gil JE; Hospital Universitario 'Dr. José Eleuterio Gonzalez', Nuevo León, México., Jimenez-Antolinez YV; Hospital Universitario 'Dr. José Eleuterio Gonzalez', Nuevo León, México., Mancías-Guerra C; Hospital Universitario 'Dr. José Eleuterio Gonzalez', Nuevo León, México., Velasco-Ruiz IY; Hospital Universitario 'Dr. José Eleuterio Gonzalez', Nuevo León, México., González-Llano O; Hospital Universitario 'Dr. José Eleuterio Gonzalez', Nuevo León, México. Electronic address: droscargonzalezllano@gmail.com.
Jazyk:	angličtina
Zdroj:	Hematology, transfusion and cell therapy [Hematol Transfus Cell Ther] 2023 Jul; Vol. 45 Suppl 2, pp. S25-S29. Date of Electronic Publication: 2021 Dec 22.
DOI:	10.1016/j.htct.2021.09.018
Abstrakt:	Introduction: Intrathecal chemotherapy is a mainstay component of acute lymphoblastic leukemia treatment. In Mexico, there is a considerable practice variability in aspects, such as the manner of preparation and the administration technique. Objective: Our objective was to describe the different techniques used for the application of ITC and review the existing recommendations in the literature. Method: A cross-sectional, nationwide survey study was conducted by an electronic questionnaire sent to hematologists and oncologists in Mexico. We collected demographic data, personal experience, intrathecal chemotherapy techniques, drug preparation and postprocedural conduct. Results: We received 173 responses. Twenty percent had an anesthesiologist administering sedation and pain management. The platelet count considered safe was 50 × 10 9 /L in 48% of the participants. In 77% (n = 133) of the cases, the conventional needle with stylet used was, 49% did not receive any added diluent in the intrathecal chemotherapy and only 42% were recommended to rest in a horizontal position for more than 30 min. Conclusion: We identified a considerable variation in the administration of intrathecal chemotherapy across the hematologists in Mexico. We discuss the implications and opportunities in reducing the variation in our setting, highlighting the unmet need to establish guidelines that should be evaluated by the Mexican professional society to produce a position paper regarding practice standardization. Competing Interests: Conflicts of interest The authors declare no conflicts of interest. (Copyright © 2021. Published by Elsevier España, S.L.U.)
Databáze:	MEDLINE
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